AU - Esmaili, Kimia AU - Amini, Kumarss TI - Detection of Human Herpes Virus Type 6 and Varicella Zoster Virus in the Urine of Patients with Multiple Sclerosis in Kerman Province, Iran PT - JOURNAL ARTICLE TA - The-Neuroscience-Journal-of-Shefaye-Khatam JN - The-Neuroscience-Journal-of-Shefaye-Khatam VO - 6 VI - 3 IP - 3 4099 - http://shefayekhatam.ir/article-1-1745-en.html 4100 - http://shefayekhatam.ir/article-1-1745-en.pdf SO - The-Neuroscience-Journal-of-Shefaye-Khatam 3 ABĀ  - Introduction: Multiple sclerosis (MS) is a demyelinating disease of the CNS in which autoimmunity to myelin plays a role in pathogenesis. Infection with common viruses, particularly varicella zoster virus (VZV) and Human herpesvirus 6 (HHV-6) are postulated to contribute to the pathobiology of MS. The aim of this study was to detect of HHV-6 and VZV in the urine samples of patients with MS in the Kerman province, Iran. Materials and Methods: In this cross-sectional study, a total of 60 non-repetitive urine samples from patients with MS and 60 urine samples from healthy people without any neurological disease and urinary tract infection were collected. The infection with HHV- 6 and VZV were investigated using multiplex PCR method. Results: Of the 60 urine samples obtained from MS patients, 23 (13.8%) and 7 (4.2%) were positive for HHV-6 and VZV, respectively. VZV and HHV-6 were not detected simultaneously in any of obtained samples. HHV-6 and VZV were not found in any samples obtained from healthy people. Conclusion: The prevalence of HHV-6 and VZV viruses in MS patients is high, which may suggest an association between MS and the presence of these viruses in this region. CP - IRAN IN - LG - eng PB - The-Neuroscience-Journal-of-Shefaye-Khatam PG - 19 PT - Research --- Open Access, CC-BY-NC YR - 2018