TY - JOUR T1 - Molecular Mechanisms of Parkinson's Disease TT - مکانیسم‌های مولکولی بیماری پارکینسون JF - The-Neuroscience-Journal-of-Shefaye-Khatam JO - The-Neuroscience-Journal-of-Shefaye-Khatam VL - 8 IS - 1 UR - http://shefayekhatam.ir/article-1-2039-en.html Y1 - 2019 SP - 120 EP - 128 KW - Mitochondria KW - Oxidative Stress KW - Dopaminergic Neurons N2 - Introduction: Parkinson's disease is a common neurodegenerative disorder. In this disease, mitochondrial defects and oxidative stress lead to the enhancement of the free radicals and the death of dopamine neurons in the Sabstantia nigra. The clinical symptoms of this disease are including tremor, muscle stiffness, and inability to walk as well as cognition, memory and learning deficits. Aging increases the severity of Parkinson's disease. Conclusion: Any therapeutic strategy which can modulate antioxidant homeostasis and neuroprotection may increase the life expectancy and quality of life of patients with Parkinson's disease. M3 10.29252/shefa.8.1.120 ER -