TY - JOUR T1 - Pathogenic and Therapeutic Role of Micrornas in Glioblastoma Multiforme TT - نقش پاتوژنیک و درمانی ریزRNA ها در گلیوبلاستوما مولتی‌فرم JF - The-Neuroscience-Journal-of-Shefaye-Khatam JO - The-Neuroscience-Journal-of-Shefaye-Khatam VL - 8 IS - 2 UR - http://shefayekhatam.ir/article-1-2086-en.html Y1 - 2020 SP - 107 EP - 118 KW - Glioblastoma KW - MicroRNAs KW - Cell Death N2 - Introduction: Glioblastoma multiforme (GBM) is a severe type of brain tumors with very poor prognosis and a median survival time of about 15 months. To identify new biomarkers and therapeutic approaches, novel methods are crucial to treat GBM, based on the biological and molecular nature of these tumors. Recently, microRNAs (miRNAs) have been extensively used with the aim of developing accurate molecular therapies, due to their emerging role in the regulation of cancer-related genes. miRNAs, a class of small non-coding RNA species, have vital roles across various biological processes, which may serve as diagnostic and prognostic tools in GBM. Conclusion: This review indicated that miRNAs signatures could be used for developing new molecular therapies to enhance the survival of GBM patients. On the other hand, miRNAs regulate a wide range of cellular functions, allowing them to modulate many pathways critical to GBM progression, including proliferation, cell death, metastasis, angiogenesis, and drug resistance. M3 10.29252/shefa.8.2.107 ER -