TY - JOUR JF - The-Neuroscience-Journal-of-Shefaye-Khatam JO - Shefaye Khatam VL - 2 IS - 4 PY - 2014 Y1 - 2014/12/01 TI - Immunomodulatory Role of Mesenchymal Stem Cells against Multiple Sclerosis TT - نقش تنظیم ایمنی سلول های بنیادی مزانشیمی در مالتیپل اسکلروز N2 - Introduction: Multiple sclerosis (MS) is an autoimmune disease of central nervous system that is characterized by the progressive loss of myelin. In addition to immunoregulatory properties, novel MS therapies promote myelin repair activities. Mesenchymal stem cells (MSCs) have been viewed as a potent tool for regenerative and immunosuppressive functions, indicating a potential therapy for MS. MSCs have immunological functions which are exerted by direct cell-to-cell contacts, secretion of stimulatory and inhibitory cytokines, and/or a combination of both mechanisms. Therefore, these cells can inhibit differentiation and proliferation of T-cell and stimulate the Th2 and regulatory T-cells through inhibitory effects on the immune system. Conclusion: In the current review, we discuss the mechanisms underlying the immunomodulatory effect of MSCs in different experimental models of MS. SP - 60 EP - 70 AU - Ghaemi, Amir AU - Babaei Abraki, Shahnaz AU - Ghasemi, Sedigheh AU - Sajadian, Azadeh AU - Togha, Mansoureh AD - Iranian Center of Neurological Research, Neuroscience Research Institute, Tehran University of Medical Sciences, Tehran, Iran. KW - Cell- and Tissue-Based Therapy KW - Immunomodulation KW - Multiple Sclerosis KW - Mesenchymal Stromal Cells UR - http://shefayekhatam.ir/article-1-319-en.html DO - 10.18869/acadpub.shefa.2.4.60 ER -