en O13: Comparing the Effect of Prazosin and Hydroxyzine on Sleep Quality in Patients Suffering From PTSD روانپزشکی Psychiatry پژوهشي Research --- Open Access, CC-BY-NC <p align="center">لطفاً به لینک انگلیسی مراجعه شود. </p> In light of the high prevalence of sleep disorders in patients suffering from post-traumatic stress disorders (PTSD), this study sought to comparing the effect of prazosin and hydroxyzine on sleep quality in this patient group. A total 100 patients suffering from PTSD were assessed (mean age: M = 35.51, SD = 6.41 28% females). Next, they were randomly assigned to one of three treatment groups: prazosin (33 patients), hydroxyzine (34 patients), or placebo (33 patients). The trial lasted for 8 weeks. Patients’ sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Items taken from the Mini International Neuropsychiatric Interview (M.I.N.I.) were used to operationalize PTSD. Compared to controls, patients treated with prazosin and hydroxyzine reported improved sleep and less nightmares. Improvement was greatest in patients treated with prazosin, as compared to hydroxyzine and placebo. Improvement in sleep was associated with amelioration of PTSD symptoms. Both prazosin and hydroxyzine can be used to treat psychopharmacologically sleep disorders and nightmares in patients suffering from PTSD, leading also to reductions in PTSD symptoms. Prazosin, Hydroxyzine, PTSD, Sleep Disorders 13 13 http://shefayekhatam.ir/browse.php?a_code=A-10-24-41&slc_lang=en&sid=1 Serge Brand Serge Brand Serge.Brand@upkbs.ch 10031947532846001985 10031947532846001985 Yes a. Psychiatric Hospital of the University of Basel, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland. b. Department of Sport, Exercise and Health Science, Division of Sport Science, University of Basel, Basel, Switzerland. a. Psychiatric Hospital of the University of Basel, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland. b. Department of Sport, Exercise and Health Science, Division of Sport Science, University of Basel, Basel, Switzerland. Mohammad Ahmadpanah Mohammad Ahmadpanah 10031947532846001986 10031947532846001986 No Research center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran. Research center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran. Parasto Sabzeie Parasto Sabzeie 10031947532846001987 10031947532846001987 No Research center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran. Research center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran. Mohammad Hosseini Mohammad Hosseini 10031947532846001988 10031947532846001988 No Research center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran. Research center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran. Saadat Torabian Saadat Torabian 10031947532846001989 10031947532846001989 No Department of Community Medicine, Hamadan University of Medical Sciences, Hamadan Iran. Department of Community Medicine, Hamadan University of Medical Sciences, Hamadan Iran. Mohammad Haghighi Mohammad Haghighi 10031947532846001990 10031947532846001990 No Research center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran. Research center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran. Leila Jahangard Leila Jahangard 10031947532846001991 10031947532846001991 No Research center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran. Research center for Behavioral Disorders and Substances Abuse, Hamadan University of Medical Sciences, Hamadan, Iran. Hafez Bajoghli Hafez Bajoghli 10031947532846001992 10031947532846001992 No Psychiatry & Psychology Research Center (PPRC), Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Psychiatry & Psychology Research Center (PPRC), Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. Edith Holsboer-Trachsler Edith Holsboer-Trachsler 10031947532846001993 10031947532846001993 No Psychiatric Hospital of the University of Basel, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland. Psychiatric Hospital of the University of Basel, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland.