en O 6: Kininogen Deficiency Ameliorates Neuroinflammation by Reducing Immune Cell Trafficking تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p style="text-align: center;"><span style="color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; text-align: center; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> <p><a name="OLE_LINK1">Enhanced immune cell trafficking into the central nervous system (CNS) and disruption of the blood brain barrier are pathophysiological hallmarks of neuroinflammatory disorders like multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, recent studies suggest that the coagulation and the contact-kinin system might also be involved in MS development. For instance, it was shown that the coagulation factor XII modulates immune cell function and bradykinin influences the integrity of the blood-brain barrier (BBB). High molecular weight kininogen (HMWK) is a central constituent of the contact-kinin system. Here, we identify HMWK as a critical player in neuroinflammation. Deficiency of HMWK renders mice less susceptible to EAE and was accompanied by decreased numbers of infiltrated lymphocytes into the CNS, whereas the distribution of immune cells was unaltered as determined by flow cytometry analysis. Preliminary <em>in vitro</em> migration experiments showed that HMWK leads to an enhanced immune cell trafficking through an endothelial cell layer.</a> Altogether, our study indicates that HMWK inhibition reduces cell invasion during autoimmune CNS disease and may offer a novel strategy to combat MS</p> Central nervous system, Mice, Animal model 6 6 http://shefayekhatam.ir/browse.php?a_code=A-10-24-824&slc_lang=en&sid=1 Monika Merker Monika Merker monika.merker@ukmuenster.de 100319475328460011714 100319475328460011714 Yes Department of Neurology, University of Muenster, Muenster, Germany Department of Neurology, University of Muenster, Muenster, Germany Susann Pankratz Susann Pankratz 100319475328460011715 100319475328460011715 No Department of Neurology, University of Muenster, Muenster, Germany Department of Neurology, University of Muenster, Muenster, Germany Alexander M Herrmann Alexander M Herrmann 100319475328460011716 100319475328460011716 No Department of Neurology, University of Muenster, Muenster, Germany Department of Neurology, University of Muenster, Muenster, Germany Heinz Wiendl Heinz Wiendl 100319475328460011717 100319475328460011717 No Department of Neurology, University of Muenster, Muenster, Germany Department of Neurology, University of Muenster, Muenster, Germany Christoph Kleinschnitz Christoph Kleinschnitz 100319475328460011718 100319475328460011718 No Department of Neurology, University Hospital Würzburg, Würzburg, Germany Department of Neurology, University Hospital Würzburg, Würzburg, Germany Kerstin Göbel Kerstin Göbel 100319475328460011719 100319475328460011719 No Department of Neurology, University of Muenster, Muenster, Germany Department of Neurology, University of Muenster, Muenster, Germany Sven G Meuth Sven G Meuth 100319475328460011720 100319475328460011720 No Department of Neurology, University of Muenster, Muenster, Germany Department of Neurology, University of Muenster, Muenster, Germany