The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1396
1
1
gregorian
2017
4
1
5
2
online
1
fulltext
en
O 9: Immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis: A Systematic Review
O 9: Immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis: A Systematic Review
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
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<p style="margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p>
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<p>Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) transplantation. Several studies have been conducted, investigating immunomodulatory effects of neural stem cells (NSCs) in order to assess their efficacy in the animal model of MS, but still controversies have remained. Our study aim was to systematically review the existing papers in the field of immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis. The systematic review was conducted according to the preferred reporting items for systematic reviews guidelines. We searched PubMed and Scopus databases based on the relevant medical subject headings (MeSH) of Immunomodulation, neural stem cell, and multiple sclerosis and all articles before January 2017 were included. The included studies had accurate data for immune mechanisms assessment and almost all reported neurologic clinical score assessment. Totally, 30 articles were eligible to be included in our systematic review out of 233 articles found at initial search. Studies showed exert immune modulation when neural stem cells (NSCs) are transplanted in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). Regarding the potent immunomodulatory effects of neural stem cells (NSCs) and their beneficial effects in experimental autoimmune encephalomyelitis (EAE), including their capacity for neuroprotection and Immunomodulation it seems that NSCs may be a new therapeutic method in MS therapy.</p>
Immunomodulation, Neuroinflammation, Neural stem cell, Multiple sclerosis, Experimental
9
9
http://shefayekhatam.ir/browse.php?a_code=A-10-24-827&slc_lang=en&sid=1
Sanaz
Sheykhian
Sanaz
Sheykhian
sanaz.shaykhian@gmail.com
100319475328460011729
100319475328460011729
Yes
Islamic Azad University, Mashhad, Iran
Islamic Azad University, Mashhad, Iran
Sajad
Sahab Negah
Sajad
Sahab Negah
100319475328460011730
100319475328460011730
No
Neuroscience Department, Mashhad University of Medical Sciences, Mashhad, Iran
Neuroscience Department, Mashhad University of Medical Sciences, Mashhad, Iran