en O 13: Ion Channels in Autoimmune Neurodegeneration تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only partially effective so far, ion channel modulation as a future strategy was brought into focus. Here, we review the status quo concerning recent findings from ion channel research in MS and its animal model, experimental autoimmune encephalomyelitis.&nbsp;</p> Multiple Sclerosis, Neuronal, Autoimmune 13 13 http://shefayekhatam.ir/browse.php?a_code=A-10-24-831&slc_lang=en&sid=1 Petra Hundehege Petra Hundehege Petra.Hundehege@ukmuenster.de 100319475328460011744 100319475328460011744 Yes University Hospital Münster, Neurology Clinic and Institute of Translational Neurology, ICB Mendelstraße 7, 48149 Münster, Germany University Hospital Münster, Neurology Clinic and Institute of Translational Neurology, ICB Mendelstraße 7, 48149 Münster, Germany