en O 19: Treatment and Porognosis of Autoimmune Encephalitis تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>AE is a serious medical condition in which the immune system attacks the brain, impairing function.&nbsp;With rapid diagnosis and appropriate treatment, many patients recover most or all functions. However, not all patients experience full recovery; with approximately 6% mortality and other patients who&nbsp;never regain significant brain and/or bodily functions. Autoimmune encephalitis can produce a wide range of neuro-psychiatric symptoms. While the term &ldquo;autoimmune encephalitis&rdquo; appears in the medical literature in the 1970&rsquo;s and 1980&rsquo;s, the first specific AE antibody was identified in 2005 when Dr. Josep Dalmua described the anti-NMDA-receptor encephalitis type. The disease occurs in men, women and children of all ages. AE is a multi-disciplinary disease. Diagnosis and treatment often requires the combined efforts of multiple&nbsp;specialists including: psychiatrists, neurologists, rheumatologists, and immunologists. As soon as a patient is diagnosed with AE, they should receive one or more of the four (4) first-line treatments.</p> <ol> <li>removal of a teratoma (if present) that could be triggering the autoimmune response</li> <li>steroids to reduce immune response and inflammation</li> <li>plasmapheresis to remove harmful antibodies from blood</li> <li>intravenous immunoglobulin (IVIG), which is believed to occupy the binding sites where harmful antibodies attach to brain cells.</li> </ol> <p>Second line treatments&mdash;immunosuppressant drugs&mdash;should be started promptly if first-line treatments fail to improve symptoms. Finally some neurologic article reported that 12% of patients had at least one relapse within two years.&nbsp;</p> Treatment, Patient, Immune system 19 19 http://shefayekhatam.ir/browse.php?a_code=A-10-24-836&slc_lang=en&sid=1 Karim Nikkhah Karim Nikkhah amir146nikkhah@gmail.com 100319475328460011749 100319475328460011749 Yes Mashhad University of Medical Sciences, Mashhad, Iran Mashhad University of Medical Sciences, Mashhad, Iran