en O 23: Anti-Inflammatory Treatment in Children with Refractory Seizure تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Epilepsy is a neurological disease of the central nervous system. It is estimated that about 50-70 million people worldwide suffer from this chronic disorder and 20 to 30% are resistant to conventional anti-epileptic drugs. In the epilepsy therapeutic arena, there is real need for developing novel antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the disease. Such treatments are still lacking. Numerous experimental and clinical findings demonstrate that brain inflammation plays a key role in the generation of seizures and the pathogenesis of epilepsy. Some conventional corticosteroid therapies are used for seizures in infantile spasm, lafora disease and Rasmussen syndrome. There are some herbal drugs that have anti-inflammatory effects but small side effects, like curcumin. Curcumin is the active component of turmeric which is used in every day cooking. Molecular investigations reveal that curcumin has anti-inflammatory, antimicrobial, anti-hepatotoxic and anti-hyperlipidemic affects. Curcumin has recently been reported to have anticonvulsant effects in several animal models of epilepsy and in our investigation, has effect on refractory myoclonic seizures in children with no significant side effect.</p> Refractory seizure, Anti-inflammatory treatment, Curcumin 23 23 http://shefayekhatam.ir/browse.php?a_code=A-10-24-840&slc_lang=en&sid=1 M Beiraghi Toosi M Beiraghi Toosi beiraghitm1@gmail.com 100319475328460011757 100319475328460011757 Yes Mashhad University of Medical Sciences, Mashhad, Iran Mashhad University of Medical Sciences, Mashhad, Iran K Hassanpour K Hassanpour 100319475328460011758 100319475328460011758 No Mashhad University of Medical Sciences, Mashhad, Iran Mashhad University of Medical Sciences, Mashhad, Iran J Akhondian J Akhondian 100319475328460011759 100319475328460011759 No Mashhad University of Medical Sciences, Mashhad, Iran Mashhad University of Medical Sciences, Mashhad, Iran F Ashrafzadeh F Ashrafzadeh 100319475328460011760 100319475328460011760 No Mashhad University of Medical Sciences, Mashhad, Iran Mashhad University of Medical Sciences, Mashhad, Iran F Ebrahimzadeh F Ebrahimzadeh 100319475328460011761 100319475328460011761 No Mashhad University of Medical Sciences, Mashhad, Iran Mashhad University of Medical Sciences, Mashhad, Iran