en P 4: The Hypothesis Detect Multiple Sclerosis in Early Stage with Saliva Testing تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p><strong>Introduction: </strong>Recent studies point to the clinical and research efficacy of saliva as a respected diagnostic aid for observing Multiple Sclerosis. The objectives of this Hypothesis are to identify novel biomarkers recognized to Multiple Sclerosis in early stage in saliva and to determine if the levels of these markers correlate with level of these Cerebrospinal fluid and blood assays and urine of diagnostic in multiple sclerosis<span dir="RTL">.</span> <strong>Materials and Methods: </strong>In total, 200 MS patients (100 women) will recruit (in early and late level). Paired samples of saliva, cerebrospinal fluid (CSF), blood serum and urine will be collected to detect osteopontin, Melatonin, Uric acid (UA), malonic dialdehyde (MDA) and oligoclonal IgG an using multiplex proteomic immunoassays<span dir="RTL">.</span> <strong>Results: </strong>we hope to changes of osteopontin, Melatonin, Uric acid (UA), malonic dialdehyde (MDA) and oligoclonal IgG in saliva testing<span dir="RTL">.</span> <strong>Conclusion: </strong>If these parameters change in secretion of salivary gland we can design Microchip to diagnose MS in early stage with saliva testing<span dir="RTL">.</span></p> Multiple sclerosis, Saliva testing, Cerebrospinal fluid, Microchip 35 35 http://shefayekhatam.ir/browse.php?a_code=A-10-24-853&slc_lang=en&sid=1 Masoomeh Mohamadpour Masoomeh Mohamadpour m.mohamadpour2817@yahoo.com 100319475328460011791 100319475328460011791 Yes Anatomy Department, Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Anatomy Department, Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Leila Kamali Dolatabadi Leila Kamali Dolatabadi 100319475328460011792 100319475328460011792 No Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran