en P 5: The Effect of Previous Endurance Exercise in Traumatic Brain Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p><strong>Introduction: </strong>It has been suggested <a href="http://topics.sciencedirect.com/topics/page/Physical_exercise">physical exercise</a> exerts neuroprotection in <a href="http://topics.sciencedirect.com/topics/page/Traumatic_brain_injury">traumatic brain injury</a>&nbsp;(<a href="http://topics.sciencedirect.com/topics/page/Traumatic_brain_injury">TBI</a>). However little information is available about the effect of endurance exercise on brain edema, inflammation and oxidant activity in diffuse TBI. Therefore, we investigated the prophylaxis effect of endurance training against&nbsp;<a href="http://topics.sciencedirect.com/topics/page/Oxidative_stress">oxidative damage</a>, inflammation and brain edema associated to neurologic outcome in diffuse TBI. <strong>Materials and Methods:&nbsp; </strong>A number of adult male rats of study sustained 8&nbsp;weeks of treadmill training before TBI induced by Marmarou method. The brain edema (determined by brain water content), inflammation (evaluated by IL-1&beta; level) and&nbsp;<a href="http://topics.sciencedirect.com/topics/page/Oxidative_stress">oxidative damage</a>&nbsp;(determined by lipid peroxidation) were evaluated in all animals at 24 hours after TBI. Outcome neurologic was determined -1, and 1, 4 and 24 h post-TBI. <strong>Results: </strong>Animals with previous exercise developed less brain edema than animals without exercise following TBI. A reduction in IL-1&beta; level was shown in group with exercise compared to group without exercise. A defect of neurologic outcome was observed following TBI in all times evaluated. Whereas this defect was not observed in exercised animals in any times. The level of lipid peroxidation was no different between and exercise and no exercise groups. <strong>Conclusion: </strong>The results of current study indicate the athletes probably have better neurologic outcome than non- athletes following diffuse TBI maybe part because of less development of brain edema and inflammation.&nbsp;</p> Traumatic brain injury, Inflammation, Lipid peroxidation, Brain edema 36 36 http://shefayekhatam.ir/browse.php?a_code=A-10-24-854&slc_lang=en&sid=1 Mohammad Abbas Bejeshk Mohammad Abbas Bejeshk 100319475328460011793 100319475328460011793 No Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Mohammad Amin Rajizadeh Mohammad Amin Rajizadeh 100319475328460011794 100319475328460011794 No Physiology Research Center, Institute of Neuropharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Physiology Research Center, Institute of Neuropharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Nasrin Soltani Nasrin Soltani 100319475328460011795 100319475328460011795 No Iran Kerman University of Islamic Azad, Kerman, Iran Iran Kerman University of Islamic Azad, Kerman, Iran Mohammad Khaksari Mohammad Khaksari 100319475328460011796 100319475328460011796 No Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran Zahra Soltani Zahra Soltani soltaniy@yahoo.com 100319475328460011797 100319475328460011797 Yes Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran