en P 16: The Effect of Reducing CCL11 on Multiple Sclerosis Treatment by Using Heterochronic Parabiosis Techniques تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p><strong>Introduction:</strong> Multiple sclerosis is a chronic neuroinflammatory disease that leads to distribute neurodegeneration in the grey and white matter of the brain. &nbsp;In MS, age-related iron accumulation, chronic oxidative injury and activation of microglia are key factors to create neurodegeneration. Also concentration of CCL₁₁ is increased in &nbsp;&nbsp;multiple sclerosis. CCL₁₁ can amplify glutamate mediated neurotoxicity and inhibit neurogenesis. <strong>Materials and Methods:</strong> A model of Heterochronic Parabiosis is created with joining a sick animal to healthy young animal. <strong>Results:</strong> It is expected by reducing CCl₁₁, healthy young blood could be effective in slowing and improving disease. <strong>Conclusion:</strong> Other studies suggest that multiple sclerosis treatment should be based on a combination of anti-inflammatory, regenerative, and neuroprotective strategies. By using heterochronic parabiosis has been shown that, young blood can rejuvenate and improve the regenerative capacity of peripheral tissues and central nervous system in aged animals. GDF₁₁ is a systemic &lsquo;pro-youthful&#39; factor in young parabiont, that promote neurogenesis and rejuvenate regeneration capacity of CNS and promote tissue regeneration.&nbsp; So it seems high concentration of GDF₁₁ and low concentration of ccl₁₁ in healthy young parabiont may be effective on regenerative capacity of central nervous system in MS animals.</p> Multiple sclerosis, Neurodegeneration, Heterochronic parabiosis, CCL11, GDF11 47 47 http://shefayekhatam.ir/browse.php?a_code=A-10-24-865&slc_lang=en&sid=1 Leila Kamali-Dolatabadi Leila Kamali-Dolatabadi leili_kamali@yahoo.com 100319475328460011842 100319475328460011842 Yes Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran Masoomeh Mohamadpour Masoomeh Mohamadpour 100319475328460011843 100319475328460011843 No Histomorphometry and Stereology Research Center. Shiraz University of Medical Science. Shiraz. Iran Histomorphometry and Stereology Research Center. Shiraz University of Medical Science. Shiraz. Iran