en P 19: The Effects of Aloe Vera Extract on Brain Edema and Blood-Brain Barrier Permeability after Traumatic Brain Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p><strong>Introduction: </strong>Recent studies have reported that the Aloe vera (Aloe barbadensis miller) plant has anti-inflammatory and antioxidant effects. This study evaluated the neuroprotective effects of different doses of Aloe vera extract after traumatic brain injury (TBI) in male rats. <strong>Materials and Methods:&nbsp; </strong>In this study, 70 male rats were divided into 2 groups; each group consists of 5 of sub-groups as following: sham, TBI, TBI + vehicle, TBI + Aloe vera extract (low dose, 200mg/kg) and TBI + Aloe vera extract (high dose, 400mg/kg) groups. TBI was induced by the Marmarou method, and Aloe vera extract was administrated intra peritoneal (ip) 30&nbsp;min after TBI. Brain edema was evaluated by measuring brain water content 24 h after the TBI and blood-brain barrier (BBB) permeability was determined by measuring Evans blue dye content 5 h after the TBI. <strong>Results: </strong>Our results showed that brain water contents was no significant difference in TBI group compared to TBI + vehicle group (<em>P</em><0.687). But Aloe vera extract administration after TBI in different doses (200, 400 mg/kg) significantly reduced brain water content in TBI group compared to TBI + vehicle group (<em>P</em><0.005). Also blood-brain barrier permeability significantly increased after TBI compared to vehicle group (<em>P</em><0.001).In addition there was no significant difference in TBI group compared to TBI + vehicle group (<em>P</em><0.742). But Aloe vera extract administration after TBI in different doses (200, 400 mg/kg) significantly reduced blood-brain barrier permeability in TBI group compared to TBI + vehicle group (<em>P</em><0.001).&nbsp; Of course, high doses of aloe vera could more effectively reduced the brain blood barrier permeability compared to low dose of aloe vera. <strong>Conclusion: </strong>The current study, show that the Aloe vera extract may be had neuroprotetection effects after TBI<span dir="RTL">. </span>However, the mechanism(s) for this effect have not yet been elucidated.</p> Tbi, Brain edema, Aloe vera 50 50 http://shefayekhatam.ir/browse.php?a_code=A-10-24-868&slc_lang=en&sid=1 Marzieh Shahriari Marzieh Shahriari 100319475328460011854 100319475328460011854 No Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Mohammad Khaksari Mohammad Khaksari khaksar38@yahoo.co.uk 100319475328460011855 100319475328460011855 Yes Physiology Research Center, Institute of Neuropharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Physiology Research Center, Institute of Neuropharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Bahram Bibak Bahram Bibak 100319475328460011856 100319475328460011856 No Faculty of Medicine, North Khorasanunivercity of Medical Sciences Faculty of Medicine, North Khorasanunivercity of Medical Sciences Affat Ramshini Affat Ramshini 100319475328460011857 100319475328460011857 No Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Abbas Shahabi Abbas Shahabi 100319475328460011858 100319475328460011858 No Department of Biochemistry, Kerman University of Medical Sciences, Kerman, Iran Department of Biochemistry, Kerman University of Medical Sciences, Kerman, Iran