en P 28: Bone Marrow-Derived Mesenchymal Stem Cells Reduces Neuroinflammation and Splenic Cytolytic CD8 + T Cells in Mice with Experimental Autoimmune Encephalomyelitis تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p><strong>Introduction:</strong> Multiple sclerosis (MS) has been recognized as a common neurodegenerative disease that occurs after an&nbsp;Auto reactive&nbsp;T cells&nbsp;against myelin antigens.&nbsp; Demyelination and inflammation are the main features of this disease. The anti-inflammatory and neuroprotective roles of bone marrow-derived mesenchymal stem cells (BM-MSCs) have been considered as a suitable treatment against autoimmune diseases. Previous studies have shown that treatment with BM-MSCs may regulate immune responses and improve the symptoms in experimental autoimmune encephalomyelitis (EAE) mice, an animal model of multiple sclerosis. Therefore, the present study was designed to evaluate immunomodulatory effects of BM-MSCs in the treatment of myelin oligodendrocyte glycoprotein (MOG) 35-55-induced EAE in C57BL/6 mice. <strong>Materials and Methods:</strong> MSCs were obtained from the bone marrow of C57BL mice, cultured with DMEM/F12, and characterized with flow cytometer for the presence of cell-surface markers for BM-MSCs. Following three passages, BM-MSCs were injected intraperitoneally into EAE mice. Immunological responses of the transplantation were evaluated. <strong>Results</strong>: The results demonstrated that BM-MSCs transplantation in EAE mice significantly reduced inflammation infiltration and demyelination, enhanced the immunomodulatory functions, and inhibited progress of neurological impairments compared to control groups. <strong>Conclusion</strong>: This study suggests the potential of BM-MSCs to induce immunomodulatory and anti-inflammatory roles in the treatment of neuroinflammatory disorders.</p> Multiple sclerosis, Stem cells, Neuroinflammation, Cytokine, Neuroprotection 59 59 http://shefayekhatam.ir/browse.php?a_code=A-10-24-877&slc_lang=en&sid=1 Amir Ghaemi Amir Ghaemi ghaem_amir@yahoo.com 100319475328460011895 100319475328460011895 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Virology, Institute Pasteur of Iran, Tehran, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Virology, Institute Pasteur of Iran, Tehran, Iran Leila Alizadeh Leila Alizadeh 100319475328460011896 100319475328460011896 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Gelareh Vakilzadeh Gelareh Vakilzadeh 100319475328460011897 100319475328460011897 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Soodeh Razeghi Jahromi Soodeh Razeghi Jahromi 100319475328460011898 100319475328460011898 No Multiple Sclerosis Research Center-Neuroscience Institute, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Multiple Sclerosis Research Center-Neuroscience Institute, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran