en P 41: Meningioma Stem Like Cells and Self Assembling Nanopeptide Scaffold for Treatment of Traumatic Brain Injury in Animal Model تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p><strong>Introduction: </strong>Brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. Using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. <strong>Materials and Methods:</strong> Human meningioma stem cells were isolated, cultured and then expanded into in vitro condition. The rat models of TBI were divided into 5 groups as follows: sham, PBS, stem cells, scaffold and stem cell + scaffold. To evaluate movement improvement and physical activity mNSS and EEG were used and to evaluate cell differentiation and inflammation response IHC was done. <strong>Results:</strong> Our results showed that mNSS were significantly improved in cell group. <strong>Conclusion:</strong> Tissue engineering is a new therapeutic method and can be promising in treating damaged parts of brain during traumatic brain injury.</p> Tissue engineering, Human meningioma stem like cells, Traumatic brain injury 72 72 http://shefayekhatam.ir/browse.php?a_code=A-10-24-890&slc_lang=en&sid=1 Pardis Oliazadeh Pardis Oliazadeh 100319475328460011936 100319475328460011936 No Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hasan Abbasian Hasan Abbasian 100319475328460011937 100319475328460011937 No Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Moniba Bijari Moniba Bijari 100319475328460011938 100319475328460011938 No Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Fateme Gholami Zohan Fateme Gholami Zohan 100319475328460011939 100319475328460011939 No Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Sajad Sahab Negah Sajad Sahab Negah Sahabsajad@yahoo.com 100319475328460011940 100319475328460011940 Yes a. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran a. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran