en P 67: The Role of Neuroinflammation in Dysfunction of Adult Hippocampal Neurogenesis تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Neuroinflammation as a protective mechanism for repairing tissue damage in the central nervous system (CNS), has been classified into two types: acute and chronic. It is characterized by the activation of microglia and astrocytes and the increase levels of different chemokines and cytokines. Neuroinflammation can be harmful, and it is a common pathological feature in neurodegenerative and psychiatric conditions. On the other word, neuroinflammation effects on important processes in the brain such as adult neurogenesis. Neurogenesis is the process by which new neurons are generated during the embryonic development of CNS and in the adult brain, and it has an important role in the repairing adult brain. Therefore, we review the effect of neuroinflammation on neurogenesis. Chronic neuroinflammation can impair to hippocampal neurogenesis in the adult brain. It has been proven that chronic neuroinflammation due to increased microglial activation and increased production of pro‐inflammatory cytokines (e.g. interleukin-1&beta;, interleukin-6, and tumor necrosis factor-&alpha;.) has deleterious effects on neurogenesis. It has been also demonstrated that microglial activation by reducing cell proliferation and newborn cell survival leads to hippocampal neurogenesis dysfunction in the adult brain. It can be concluded that neurogenesis as a physiologic phenomenon in hippocampus affected by neuroinflammation. New studies in this field can be helped to treat related neurodegeneration disease.&nbsp;</p> Neuroinflammation, Central nervous system, Acute, Chronic, Neurogenesis 98 98 http://shefayekhatam.ir/browse.php?a_code=A-10-24-917&slc_lang=en&sid=1 Farideh Baghishani Farideh Baghishani baghishanif2@mums.ac.ir 100319475328460012018 100319475328460012018 Yes Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Sajad Sahab Negah Sajad Sahab Negah 100319475328460012019 100319475328460012019 No a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Neda Fazaeli javan Neda Fazaeli javan 100319475328460012020 100319475328460012020 No Departman of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran Departman of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran Ehsan Baghishani Ehsan Baghishani 100319475328460012021 100319475328460012021 No Islamic Azad University, Mashhad Branch, Mashhad, Iran Islamic Azad University, Mashhad Branch, Mashhad, Iran