The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1396
1
1
gregorian
2017
4
1
5
2
online
1
fulltext
en
P 68: The Role of Neuroinflammation in Post-Traumatic Stress Disorder (PTSD)
P 68: The Role of Neuroinflammation in Post-Traumatic Stress Disorder (PTSD)
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
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<p>Post-traumatic stress disorder (PTSD) is an anxiety disorder that can typically occur after traumatic events in which the individual felt sever helplessness or horror. PTSD has a lifetime prevalence of 5–8% and women show higher prevalence than in compared with men. Neuroinflammation is associated to anxiety and related disorders such as PTSD. It is an early, specialized immune reaction fallowing tissue damage and/or pathogen invasion in the central nervous system (CNS). Regarding the importance of anxiety disorders especially PTSD and their effect on patients' personal and social life, considering of the neuroinflammation in PTSD can be used for new treatment. Several studies have been reported that there is a relationship between neuroinflammation and PTSD. Current epidemiological evidence shows that increased expression of pro‐inflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α, and decreased anti-inflammatory factors have a key role in creating PTSD. Also, neuroinflammation induced by inhibition of the NADPH oxidase (NOX2) can lead to trigger the PTSD symptoms. Various inflammatory markers such as Cortisol, C-reactive protein (CRP), Th1 cytokines, and Th2 Cytokines are associated with PTSD. Furthermore, micro<span dir="RTL">÷</span>glial activation may also initiate inflammation and can be involved in PTSD. Thus, scrutinized research about PTSD and understanding of creating mechanisms of this disorder is essential and can provide grounds for its treatment.</p>
Neuroinflammation, Post-traumatic stress disorder, Central nervous system
99
99
http://shefayekhatam.ir/browse.php?a_code=A-10-24-918&slc_lang=en&sid=1
Farideh
Baghishani
Farideh
Baghishani
baghishanif2@mums.ac.ir
100319475328460012022
100319475328460012022
Yes
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Sajad
Sahab Negah
Sajad
Sahab Negah
100319475328460012023
100319475328460012023
No
a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
Ehsan
Baghishani
Ehsan
Baghishani
100319475328460012024
100319475328460012024
No
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Islamic Azad University, Mashhad Branch, Mashhad, Iran