en P 75: Inflammation in the Pathogenesis of Depression تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Depression is a mental disorder that results from changes in the central nervous system (CNS) that may result from immunological abnormalities. According to the World Health Organization<span dir="RTL">,</span> major depression will become the leading cause of disability worldwide. Accumulating evidence has indicated the existence of reciprocal communication pathways between nervous, endocrine and immune systems. The immune system affects the CNS through cytokines<span dir="RTL">,</span> which regulate brain activities and emotions. Cytokines affect the activity of the two biological systems that are most associated with the pathophysiology of depression: The hypothalamic-pituitary-adrenal axis and the catecholamine/sympathetic nervous system. Pro-inflammatory cytokines and stress are important in inflammatory and neurogenesis and neuroprotection. Stress induces pro-inflammatory cytokines over secretion<span dir="RTL">,</span> which result in activation the HPA axis and neurotransmitter turnover<span dir="RTL">,</span> thus leading to depression. The use of cytokine inhibitors and anti-inflammatory drug is effective in the treatment of the depression. Although there are known effective treatment for depression<span dir="RTL">,</span> fewer than half of these affected in the world. In this review calculated recent literature related to the effect of inflammation on the pathogenesis depression.</p> Inflammation, Central nervous system, Cytokine, Endocrine, Stress 106 106 http://shefayekhatam.ir/browse.php?a_code=A-10-24-925&slc_lang=en&sid=1 Mohadese Ghanei Sarcheshmeh Mohadese Ghanei Sarcheshmeh ghaneism931@mums.ac.ir 100319475328460012035 100319475328460012035 Yes Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran