The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1396
1
1
gregorian
2017
4
1
5
2
online
1
fulltext
en
P 77: The Role of Interleukin-1 in Neurogenesis and Alzheimer Disease
P 77: The Role of Interleukin-1 in Neurogenesis and Alzheimer Disease
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
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<p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p>
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<p>One of the most serious neurodegenerative disorders is Alzheimer disease (AD). As the population is aging and due to the fact that AD is more common in aged people, more attention must be paid to this disease. One of the main characteristics of AD is dementia which starts with loss of short term memory, then progresses and causes various brain dysfunctions such as loss of long term memory. Interleukin-1 is a pluripotent cytokine that initiates inflammatory responses in different parts of body such as brain. In a study, it has been shown that IL-1 upregulates the expression of β-amyloid precursor protein (β-APP) that plays an important role in AD pathogenesis. A previous study represents that IL-1 induces production of substrates that are essential for making neuropathological changes characteristic of AD. Another research says that IL-1 affects the pathogenesis of AD through increasing the translation of APP mRNA. Interestingly an article claims that IL-1β-driven neuroinflammation has a possible adaptive role in AD. It has been broadly demonstrated that neuroinflammation influences adult neurogenesis. The duration of inflammation leads to inhibition or promotion of neurogenesis. Hence, modulating neuroinflammatory cytokines such as IL-1 may help in the prevention of AD or halting its progression.</p>
Neuroinflammation, Alzheimer disease, Interleukin-1
108
108
http://shefayekhatam.ir/browse.php?a_code=A-10-24-927&slc_lang=en&sid=1
Amir Mahmoud
Ahmadzade
Amir Mahmoud
Ahmadzade
100319475328460012038
100319475328460012038
No
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Farzin
Naseri
Farzin
Naseri
100319475328460012039
100319475328460012039
No
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Sajad
Sahab Negah
Sajad
Sahab Negah
SahabNegahS@mums.ac.ir
100319475328460012040
100319475328460012040
Yes
a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran