The Neuroscience Journal of Shefaye Khatam

ar P 87: The Amyloid Beta as a Therapeutic Target in Alzheimer Disease P 87: The Amyloid Beta as a Therapeutic Target in Alzheimer Disease تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Alzheimer disease (AD) is a neurodegenerative disorder marked by cognitive and behavioral impairment. Amyloid beta (Aβ) peptides are involved in AD as the main component of amyloid plaques found in the brain. Recent in vivo and in vitro studies have shown that there is a lot of substances that alter Aβ pathogenesis of AD. Aβ induces toxicity lead to increasing ROS. In the other hand, 5-HT6 and Aloe arborescence recently reported to protect cells from this effect. Additionally, Aβ oligomers interact with neurons through Nrx2a and NL1 receptors by blocking these receptors; one can reduce the Aβ-induced memory impairment. Moreover, Aβ aggregation correlates with high concentration of Fe (III) and Cu (II). And chelators decreased significantly aggregation of Aβ in synaptic cleft. By knowing the mechanism of Aβ toxicity, new therapeutic approaches can be developed to prevent AD or alleviate disability caused by it. JC-124 treatment leads to decrease levels of Aβ deposition. Bosentan, a dual endothelin receptor antagonist, offers protection against Aβ-induced endothelial damage. Anti Nrx2a andante NL1 reduces Aβ-induced memory impairment in mice. Clicaquinol inhibits disaggregation of Aβ at low pHs. In this article we review the substances that have a role in the toxicity of Aβ and can be considered as a new target for the management of AD.</p> Amyloid beta, Alzheimer disease, Neurodegenerative, Treatment 118 118 http://shefayekhatam.ir/browse.php?a_code=A-10-24-937&slc_lang=ar&sid=1 Mohammad Javad Imen Mohammad Javad Imen imenmj912@gmail.com 100319475328460012061 100319475328460012061 Yes Islamic Azad University, Mashhad Branch, Medicine Faculty, Mashhad, Iran Islamic Azad University, Mashhad Branch, Medicine Faculty, Mashhad, Iran Reza Bayattork Reza Bayattork 100319475328460012062 100319475328460012062 No Islamic Azad University, Mashhad Branch, Medicine Faculty, Mashhad, Iran Islamic Azad University, Mashhad Branch, Medicine Faculty, Mashhad, Iran