en P 88: Matrix Metalloproteinases in Neuroinflammation تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood&ndash;brain barrier (BBB) by degrading the components of the basal lamina and contribute to the neuroinflammatory response in several neurological diseases. In response to cellular stress the brain cells express both constitutive and inducible MMPs. The MMPs belong to a larger class of metalloproteinases (MPs), which includes proteins containing a disintegrin and metalloproteinase domain (ADAM). MPs have complex roles at the cell surface and in the extracellular matrix. At the cell surface they are essential for cell survival and death. MMPs are inhibited by specific endogenous tissue inhibitors of metalloproteinases&nbsp;(TIMPs) that regulate the activity of them. MMP inhibitors have been developed for the treatment of several neurological disorders such as Alzheimer&rsquo;s disease, Multiple sclerosis, spinal cord injury, and traumatic brain injury. Since MMPs have both beneficial and detrimental roles; understanding their expression in numerous CNS insults and the use of MMP inhibitors is a good topic for scientists that will help in the treatment of the neurological disease.&nbsp;</p> Matrix metalloproteinases, Neuroinflammation, Extracellular matrix 119 119 http://shefayekhatam.ir/browse.php?a_code=A-10-24-938&slc_lang=en&sid=1 Fatemeh Forouzanfar Fatemeh Forouzanfar 100319475328460012063 100319475328460012063 No Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Bagher Khorrami Mohammad Bagher Khorrami 100319475328460012064 100319475328460012064 No a. Department of New Sciences and Technology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Social Security Organization, 17th Shahrivar Hospital, Mashhad, Iran a. Department of New Sciences and Technology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Social Security Organization, 17th Shahrivar Hospital, Mashhad, Iran Sajad Sahab Negah Sajad Sahab Negah sahabsajad@yahoo.com 100319475328460012065 100319475328460012065 Yes Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran