en P 90: The Role of miR-146a in Inflammatory Process of Mesial Temporal Lobe Epilepsy (MTLE): Implication for Therapy تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Epilepsy is the third most common chronic brain disorder which is characterized by an enduring predisposition to generate seizures. Mesial Temporal Lobe Epilepsy (MTLE) is the most common type of refractory epilepsy. Increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of MTLE. Hundreds of micro-RNAs have been found to be abnormally expressed in epileptic tissues, whereas only several mi-RNAs, such as miR-146&alpha; have been reported to function in the pathological process of epilepsy. &nbsp;The miR-146a has been recently identified as a potentially endogenous regulator of TLR (Toll like Receptor) and cytokine receptor signaling, suggesting a link between mi-RNAs and inflammatory process in diseases like epilepsy. Up-regulation of both IL-1 &nbsp;and miR-146a expression levels associated with seizures in animal models and human MTLE, supporting the hypothesis that IL-1 &nbsp;and miR-146a are mediators of inflammation, which facilitate the epileptic process. Despite the recent advent of additional antiepileptic drugs (AEDs) and respective surgery, the treatment of epilepsy remains a major challenge. Understanding the role of miR-146a MTLE&ndash;associated pathologies may be relevant for the development of new therapeutic strategies. Therefore the aim of this paper is to introduce miR-146a as a recommended therapy for epilepsy in future studies. MiR-146a and specific inflammation related pathways, are as a probable therapy for some MTLE patients who are resistant to available AEDs.</p> Neuroinflammation, Mesial temporal lobe epilepsy, miR-146α 121 121 http://shefayekhatam.ir/browse.php?a_code=A-10-24-940&slc_lang=en&sid=1 Sarah Banakermani Sarah Banakermani s.banakermani@gmail.com 100319475328460012072 100319475328460012072 Yes Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohadese Hasanzadeh Kahani Mohadese Hasanzadeh Kahani 100319475328460012073 100319475328460012073 No Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran