en P 94: The Systemic Inflammation after Spinal Cord Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Spinal cord injury (SCI) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms. Neuroinflammation is an important secondary injury process in SCI. The local inflammatory microenvironment within the injured spinal cord is a collection of degenerating neurons, damaged endothelial cells, degraded myelin sheath, and this microenvironment produces various kinds of pro-inflammatory mediators. There are many other factors such as dysregulation of the neuroendocrine system and changed neuroimmune regulation that important determinant of the onset and progression of post-SCI systemic inflammation. Epidemiological analyses have unfolded a functional link between systemic inflammation and pathogeneses of post-injury complications. On the other hand cognitive impairment is associated with extensive cerebral inflammation after SCI. SCI triggers systemic inflammatory responses marked by increased circulation of immune cells and pro-inflammatory mediators, which result in the permeation of inflammatory cells into secondary organs and durability of an inflammatory microenvironment that chip in organ dysfunction.&nbsp;</p> Spinal cord injury, Inflammation, Neuroendocrine 125 125 http://shefayekhatam.ir/browse.php?a_code=A-10-24-944&slc_lang=en&sid=1 Sara Abdolahi Sara Abdolahi abdolahisara65@gmail.com 100319475328460016633 100319475328460016633 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Zahra Aeini Zahra Aeini 100319475328460016634 100319475328460016634 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Robabeh Jafari Robabeh Jafari 100319475328460016635 100319475328460016635 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Zeinab Najmi Zeinab Najmi 100319475328460016636 100319475328460016636 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Microbial biotechnology group, Faculty of Basic Sciences, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Microbial biotechnology group, Faculty of Basic Sciences, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran Maryam Jafari Maryam Jafari 100319475328460016637 100319475328460016637 No Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Ali Jahanbazi Jahan Abad Ali Jahanbazi Jahan Abad 100319475328460016638 100319475328460016638 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran