The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1396
1
1
gregorian
2017
4
1
5
2
online
1
fulltext
en
P 105: The Role of LRRK2 Inhibitors in Treatment of Parkinson’s Disease
P 105: The Role of LRRK2 Inhibitors in Treatment of Parkinson’s Disease
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
<table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%">
<tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;">
<tr style="break-inside: avoid !important;">
<td class="abstractmed" colspan="2" style="break-inside: avoid !important;">
<p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p>
</td>
</tr>
<tr style="break-inside: avoid !important;">
</tr>
</tbody>
</table>
<p></p>
<p>Parkinson’s disease is the second most common age associated neuron degenerative disorder in developed societies. With the prevalence ranging from 41 per 100000 in the fourth decade of life to over 1900 per 100000 in people over 80 years of age.it characterized clinically by resting tremor, slowness of movement, rigidity and postural instability in the result of progressive loss of dopaminergic neurons in the substantia nigra. Although a variety of possible pathogenic mechanisms have been proposed over the years its etiology has not yet been fully understood. Chronic inflammation is one of the etiologies of Parkinson’s disease and play vital role in the degeneration of dopaminergic neurons. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are found in Parkinson’s disease, as in immune related disorder including Crohn’s disease and leprosy. Increasing evidence suggests that LRRK2 protein play an important role in innate immunity. A process that occurs in neurodegenerative disease including Parkinson’s disease.LRRK2 is a large and complex protein with a unique multiple domain architecture and that can function as a protein kinase with many putative substrates identified and can also function as a GTPase that may serve in part to regulate kinase activity. The combined genetic and biochemical evidence supports a hypothesis in which the LRRK2 kinase function is involved in the pathogenesis of sporadic and familial form of Parkinson’s disease. This finding suggests that LRRK2 kinase inhibitors may potentially offer new treatment for Parkinson’s disease.</p>
Neuroinflammation, Parkinson’s disease, LRRK2 inhibitors
136
136
http://shefayekhatam.ir/browse.php?a_code=A-10-24-955&slc_lang=en&sid=1
Maryam
Irannejad
Maryam
Irannejad
maaryam.irannejad@gmail.com
100319475328460012114
100319475328460012114
Yes
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Mahdie
Abbasi
Mahdie
Abbasi
100319475328460012115
100319475328460012115
No
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Islamic Azad University, Mashhad Branch, Mashhad, Iran