en P 106: Effects of Dimethyl Sulfoxide on NLRP3 Inflammasome and Alzheimer's Disease تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Alzheimer&#39;s disease (AD), the most ordinary form of dementia and extracellular accumulation of Amyloid-&beta; (A&beta;) in senile plaques, is an important and a main event in the pathogenesis of AD. Deposition of A&beta; Peptide initiates a spectrum of cellular responses that are interposed by the resident neuroimmune cells of the brain, the microglia. Recently, a novel inflammasome signaling&nbsp; pathway has been uncovered and A&beta; can activate the NLRP3 inflammasome in microglia, which is fundamental for the secretion&nbsp; of pro-inflammatory cytokines&nbsp; and subsequent inflammatory events .More importantly , the activation of&nbsp; NLRP3 inflammasome has demonstrated&nbsp; a serious role in AD pathogenesis by interposing a harmful chronic inflammatory response, while inhibition of&nbsp; NLRP3 mainly protected from loss of spatial memory and decreased A&beta; deposition in an AD mouse model. Dimethyl Sulfoxide (DMSO) is an amphipathic molecule that is widely used as a solvent for biological compounds .In addition, DMSO has been studied as a medicine for the treatment of inflammation, cystitis, and arthritis. Based on the anti-inflammatory characteristics of DMSO,&nbsp; the effects of DMSO on activation of inflammasomes has elucidated, which are cytoplasmic multi-protein complexes&nbsp; that interpose the maturation of interleukin (IL)-1&beta; by activating caspase-1 (casp1). The aim is discussing about effects of DMSO on NLRP3 inflammasome and AD. It has proved that DMSO attenuates IL-1&beta; maturation, casp1 activity, and ASC pyroptosome formation by NLRP3 inflammasome activators. DMSO is a selective inhibitor of the NLRP3 inflammasomes. The anti-inflammatory effect of DMSO was further proved in animal studies, LPS-endotoxin sepsis, and inflammatory bowel disease models. DMSO shows anti-inflammatory characteristics, attenuates NLRP3 inflammasome activation. According to studies, it is hypothesized that DMSO inhibits activation of inflammasomes, NLRP3, CASP1 in Alzheimer&#39;s disease that are pathogenesis by mediating a harmful chronic inflammatory response.</p> Alzheimer's disease, NLRP3, Casp1, Inflammasome, DMSO 137 137 http://shefayekhatam.ir/browse.php?a_code=A-10-24-956&slc_lang=en&sid=1 Reyhane Shahraki Reyhane Shahraki reyshah75@gmail.com 100319475328460012116 100319475328460012116 Yes Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran