The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1396
1
1
gregorian
2017
4
1
5
2
online
1
fulltext
en
P 107: P2x7 Receptors: as a Novel Targets for the Treatment of Neuroinflammation
P 107: P2x7 Receptors: as a Novel Targets for the Treatment of Neuroinflammation
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
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<p>P2x7 receptors are Purineric receptors that are extracellular ATP-gated ion channel. These receptors require high dose or prolonged exposure to ATP for initial activation. The Activation of these receptors facilitates the formation of inflammasome which activates caspase 1. The P20 and P10 subunits of caspase 1 form active enzyme that then releases active interleukin (IL)-1 β and IL-18, tumor necrosis Factor-α (TNF-α), IL-6 important proinflammatory cytokines which can induce inflammation Although other cytokines such as, IL-8, IL-1α, IL-2, IL-4, IL-13 Can be released by activation p2x7 receptors. P2X7 receptors are widely expressed in neurons, microglia, astrocytes, oligodendrocytes and Schwann cells where they can induce neuroinflammation also neuroinflammation is an essential step in neurodegenerative inflammatory diseases which include: multiple Sclerosis, Alzheimer's, Parkinson's, Huntington’s disease, atrophic lateral sclerosis, frontotemporal dementia, and traumatic brain injury also previous study in recent years reports overexpression of p2x7 receptors in neuroinflammation subsequently neurodegenerative diseases. In this study we aim to overview the role of p2x7 receptors in neuroinflammation as a novel targets for the treatment of neuroinflammation. P2X7R emerges as a promising target to treat neuroinflammation because this receptor is involved in the release of proinflammatory cytokines that play an essential role in the development of neuroinflammation subsequently neurodegenerative diseases so an antagonist for this receptor might halt the inflammatory cascade and thus further progression of neurodegeneration.</p>
Neuroinflammation, p2x7r, Treatment, Neurodegenerative
138
138
http://shefayekhatam.ir/browse.php?a_code=A-10-24-957&slc_lang=en&sid=1
Mokhtar
Ahmadi
Mokhtar
Ahmadi
mokhtarahmadi88@yahoo.com
100319475328460012117
100319475328460012117
Yes
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Pouya
Ghaderi
Pouya
Ghaderi
100319475328460012118
100319475328460012118
No
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Mohammad Reza
Khojasteh
Mohammad Reza
Khojasteh
100319475328460012119
100319475328460012119
No
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Islamic Azad University, Mashhad Branch, Mashhad, Iran