en P 108: Evaluation of Calcineurin Role in Neuroinflmmation: Possible Targets for Early Detection and Treatment تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Calcineurin (CaN) is a Ca2+/calmodulin (Ca2+/CaM)-dependent serine/threonine protein phosphatase expressed in most mammalian tissues but found at higher concentration in brain. In the last decade there have been a steadily increasing number of studies identifying neuronal CaN as a primary suspect in neuronal vulnerability, synapse loss, dendritic atrophy, synaptic dysfunction and neuroinflammation Subsequently despite the apparently selective association of CaN with neurons and neuronal signaling cascades, many studies found that CaN, can also appear in primary glial cells and glial cells of healthy brain tissue and astrocytes, prominently following inflammatory insult The clear connection between glial cells / astrocytes and neuroinflammatory signaling, in addition to the well-known the role of CaN in cytokine production in peripheral immune cells, suggested a potent association between glial CaN and the neuroinflammation inherent to most acute and chronic neuroinflammatory autoimmune diseases. In this review we aim to evaluate the Calcineurin role in neuroinflammation as an early event. Recent studies highly confirmed CaN as a major modulator of immune/inflammatory processes in glial cells and astrocytes that higher expression of CaN associated with early stage of neuroinfllammatory autoimmune disease that makes CaN as novel target for early detection and treatment of neuroinflammatory autoimmune diseases.</p> Calcineurin, Neuroinflmmation, Early detection, Treatment 139 139 http://shefayekhatam.ir/browse.php?a_code=A-10-24-958&slc_lang=en&sid=1 Mokhtar Ahmadi Mokhtar Ahmadi 100319475328460012120 100319475328460012120 No Islamic Azad University, Mashhad Branch, Mashhad, Iran Islamic Azad University, Mashhad Branch, Mashhad, Iran Hossein Feizi Hossein Feizi h.feyzi28974@gmail.com 100319475328460012121 100319475328460012121 Yes Islamic Azad University, Mashhad Branch, Mashhad, Iran Islamic Azad University, Mashhad Branch, Mashhad, Iran Fatemeh Shahbeigi Fatemeh Shahbeigi 100319475328460012122 100319475328460012122 No Islamic Azad University, Mashhad Branch, Mashhad, Iran Islamic Azad University, Mashhad Branch, Mashhad, Iran