en P 118: Osteopontin: An Early Player in Neuroinflammation Disease تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <p>Osteopontin also known as bone sialoprotein (BSP). Osteopontin role as a linking protein. it is an extracellular structural protein and therefore an organic component of bone. Osteoprontin (OPN) binds to several integrin receptors containing &alpha;<span dir="RTL">4</span>&beta;<span dir="RTL">1</span>, &alpha;<span dir="RTL">9</span>&beta;<span dir="RTL">1</span>, and &alpha;<span dir="RTL">9</span>&beta;<span dir="RTL">4 </span>expressed by leukocytes. These receptors have been well-stable to function in cell adhesion, migration, and survival in these cells. It has been shown that OPN drives IL-<span dir="RTL">17 </span>production.as we know it has important effect on neuroinflammation Biomarkers qualified of predicting the clinical method and the level of disease progression in multiple sclerosis are currently unavailable. Our objective is to examine if the levels of proteins associated with axonal and neuronal degeneration T-cell-mediated autoimmunity (Osteopontin) are altered in the cerebrospinal fluid (CSF) of MS patients, and to assess their potential in reflecting the clinical severity and predicting the progression and clinical evolution of early MS.&nbsp;</p> Osteopontin, Neuroinflammation, Bone sialoprotein, Cerebrospinal fluid 149 149 http://shefayekhatam.ir/browse.php?a_code=A-10-24-969&slc_lang=en&sid=1 Reza Hoseini Reza Hoseini reza.h13579@gmail.com 100319475328460012142 100319475328460012142 Yes Islamic Azad University, Mashhad Branch, Mashhad, Iran Islamic Azad University, Mashhad Branch, Mashhad, Iran Mokhtar Ahmadi Mokhtar Ahmadi 100319475328460012143 100319475328460012143 No Islamic Azad University, Mashhad Branch, Mashhad, Iran Islamic Azad University, Mashhad Branch, Mashhad, Iran Parisa Asadi Parisa Asadi 100319475328460012144 100319475328460012144 No Islamic Azad University, Mashhad Branch, Mashhad, Iran Islamic Azad University, Mashhad Branch, Mashhad, Iran