The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1396
1
1
gregorian
2017
4
1
5
2
online
1
fulltext
en
P 118: Osteopontin: An Early Player in Neuroinflammation Disease
P 118: Osteopontin: An Early Player in Neuroinflammation Disease
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
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<p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p>
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<p>Osteopontin also known as bone sialoprotein (BSP). Osteopontin role as a linking protein. it is an extracellular structural protein and therefore an organic component of bone. Osteoprontin (OPN) binds to several integrin receptors containing α<span dir="RTL">4</span>β<span dir="RTL">1</span>, α<span dir="RTL">9</span>β<span dir="RTL">1</span>, and α<span dir="RTL">9</span>β<span dir="RTL">4 </span>expressed by leukocytes. These receptors have been well-stable to function in cell adhesion, migration, and survival in these cells. It has been shown that OPN drives IL-<span dir="RTL">17 </span>production.as we know it has important effect on neuroinflammation Biomarkers qualified of predicting the clinical method and the level of disease progression in multiple sclerosis are currently unavailable. Our objective is to examine if the levels of proteins associated with axonal and neuronal degeneration T-cell-mediated autoimmunity (Osteopontin) are altered in the cerebrospinal fluid (CSF) of MS patients, and to assess their potential in reflecting the clinical severity and predicting the progression and clinical evolution of early MS. </p>
Osteopontin, Neuroinflammation, Bone sialoprotein, Cerebrospinal fluid
149
149
http://shefayekhatam.ir/browse.php?a_code=A-10-24-969&slc_lang=en&sid=1
Reza
Hoseini
Reza
Hoseini
reza.h13579@gmail.com
100319475328460012142
100319475328460012142
Yes
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Mokhtar
Ahmadi
Mokhtar
Ahmadi
100319475328460012143
100319475328460012143
No
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Parisa
Asadi
Parisa
Asadi
100319475328460012144
100319475328460012144
No
Islamic Azad University, Mashhad Branch, Mashhad, Iran
Islamic Azad University, Mashhad Branch, Mashhad, Iran