en P 148: The Role of Cannabinoids in Ischemia Stroke تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <table border="0" cellpadding="5px" cellspacing="2" dir="rtl" id="table_article" style="font-family: Tahoma; background-color: rgb(251, 250, 249); break-inside: avoid !important;" width="100%"> <tbody style="break-inside: avoid !important; font-size: 12px; margin-top: 0px; line-height: 2.2; margin-bottom: 0px; text-align: justify;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="break-inside: avoid !important;"> <p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p></p> <pre> Inflammation serves a protective function in controlling infections and promoting tissue repair, and can also cause damage to tissue and disease. Many types of cells involved in this process, expressing the components of the cannabinoid signaling system that can be controlled endogenously or pharmacologically. Cannabinoids inhibit neuroinflammation and the immune cells express the whole machine which constitutes a functional cannabinoid signaling system. Two cannabinoids G receptors coupled to proteins were cloned; CB1 receptors were expressed primarily by neurons and CB2 receptors, which are mainly expressed by immune cells. Cannabinoids have anti-inflammatory effects Animal models of neuroinflammation. Inflammation of the central nervous system can be occurred as a secondary injury in Ischemic stroke is a major cause of death and disability in major industrialized countries. It has been reported that activation of CB1 and CB2 receptors prevented neuronal death in response to ischemia. We suggested the evaluation of agonist or antagonist of cannabinoid receptors may be effective on apoptosis and inflammation in ischemic stroke.</pre> Cannabinoid, Ischemia, Neuro-inflammation, CB1, CB2 179 179 http://shefayekhatam.ir/browse.php?a_code=A-10-24-999&slc_lang=en&sid=1 Mohammad Bagher Khorrami Mohammad Bagher Khorrami 100319475328460012223 100319475328460012223 No a. Department of New Sciences and Technology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Social Security Organization, 17th Shahrivar Hospital, Mashhad, Iran a. Department of New Sciences and Technology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Social Security Organization, 17th Shahrivar Hospital, Mashhad, Iran Fatemeh Forouzanfar Fatemeh Forouzanfar 100319475328460012224 100319475328460012224 No Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hamid R Sadeghnia Hamid R Sadeghnia 100319475328460012225 100319475328460012225 No a. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Neurocognitive Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran a. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Neurocognitive Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Sajad Sahab Negah Sajad Sahab Negah Sahabsajad@yahoo.com 100319475328460012226 100319475328460012226 Yes Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran