The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1397
1
1
gregorian
2018
4
1
6
2
online
1
fulltext
en
O14: Application of Neural Stem Cells Derived from Human Meningioma in Traumatic Brain Injury
O14: Application of Neural Stem Cells Derived from Human Meningioma in Traumatic Brain Injury
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
پژوهشي
Research --- Open Access, CC-BY-NC
<div style="text-align: center;"><span style="text-align: center; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; font-size: 12px; font-style: normal; font-weight: 400; word-spacing: 0px; float: none; display: inline !important; white-space: normal; orphans: 2; widows: 2; background-color: rgb(251, 250, 249); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;">لطفاً به چکیده انگلیسی مراجعه شود.</span></div>
<p style="text-align: justify;">Traumatic brain injury is considered as one of the main causes of morbidity and mortality worldwide. Apart from primary mechanical injury, Secondary injuries due to inflammation and apoptosis result in great neuronal damage. Current treatments are not able to regenerate the damaged part and prevent future sequels. Using human stem cells with self-assembling scaffolds may be promising in treatment of traumatic brain injury. Human meningioma stem cells were isolated, cultured and expanded into in vitro condition. The rat models of TBI were divided into 5 groups: sham, PBS, stem cells, scaffold and stem cell+scaffold. mNSS and EEG were performed to evaluate movement and physical activity. IHC were done to assess cell differentiation. Inflammation and apoptosis markers like toll like receptors, caspase 3,8 and TNF-a were analyzed using western blotting and PCR methods. Results showed that inflammation was significantly reduced in cell group. Tissue engineering as a new therapeutic method can be promising in treating brain damage.</p>
Neural Tissue Enginnering, Trauamtic Brain Injury, Human Neural Stem Cells
14
14
http://shefayekhatam.ir/browse.php?a_code=A-10-24-1080&slc_lang=en&sid=1
Sajad
Sahab Negah
Sajad
Sahab Negah
100319475328460015389
100319475328460015389
No
a. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
a. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
Pardis
Oliazadeh
Pardis
Oliazadeh
100319475328460015390
100319475328460015390
No
Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ali
Jahanbazi Jahan Abad
Ali
Jahanbazi Jahan Abad
100319475328460015391
100319475328460015391
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
Arezou
Es'haghabadi
Arezou
Es'haghabadi
100319475328460015392
100319475328460015392
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
Sedigheh
Ghasemi
Sedigheh
Ghasemi
100319475328460015393
100319475328460015393
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
Fatemeh
Gholami
Fatemeh
Gholami
100319475328460015394
100319475328460015394
No
Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ali
Gorji
Ali
Gorji
gorjial@uni-muenster.de
100319475328460015395
100319475328460015395
Yes
a. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran c. Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany
a. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran c. Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany