en P11: Assess the Electrophysiological Activity of Olfactory Bulb in the Animal Model of PTSD and its Relationship with Neuroinflammation in the Olfactory Bulb تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p style="text-align: justify;">Post-traumatic stress disorder (PTSD) is a mental health condition that&#39;s triggered by a terrifying event - either experiencing it or witnessing it. In addition to the relationship between PTSD and neuroinflammation, research indicates that olfactory bulb are effective in anxiety disorders. The aim of this study was to assess the electrophysiological activity of olfactory bulb in the animal model of PTSD and its relationship with neuroinflammation in its area. 36 rats were divided into two groups: control and experiment. The modified Zoladz method was used to establish a PTSD animal model. Then, behavioral tests (open field (OF) and elevated plus maze (EPM)), electrophysiological evaluation (field potential) of olfactory bulb, and assessment of serum cortisol (as an inflammatory marker) were done. It was followed by dissection of the rat&rsquo;s brains, which could be apply for analysis of neurogenesis and inflammatory factors. In OF test, the time spent in the central area and in EPM test, the time spent in the open arm by the animals of experiment group were lower than that of control group (P<0.05- P<0.01). Moreover, experiment group significantly increased slope, slope 10-90%, amplitude of fEPSP, and also cortisol level compared to control group (P<0.001). Based on our findings, it is concluded that can be a relationship between PTSD and olfactory bulb function. Of course, more molecular investigations have been conducted in order to determine the effect of PTSD on the activity of Mitral and Tufted cells, and its association with neurogenesis and inflammation in olfactory bulb, which helps to identify the role of olfactory bulb in PTSD disorder.</p> Post-Traumatic Stress Disorder, Neuroinflammation, Olfactory Bulb 42 42 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1128&slc_lang=en&sid=1 Farideh Baghishani Farideh Baghishani 100319475328460015478 100319475328460015478 No Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Sadegh Rahimi Sadegh Rahimi 100319475328460015479 100319475328460015479 No Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran Mohadeseh Ragerdi Kashani Mohadeseh Ragerdi Kashani 100319475328460015480 100319475328460015480 No Department of Immunology, Mashhad University of Medical Sciences, Mashhad, Iran Department of Immunology, Mashhad University of Medical Sciences, Mashhad, Iran Nikoo Saeedi Nikoo Saeedi 100319475328460015481 100319475328460015481 No Member of Mashhad Neuroscience Research Group of Islamic Azad University, Mashhad Branch, Mashhad, Iran Member of Mashhad Neuroscience Research Group of Islamic Azad University, Mashhad Branch, Mashhad, Iran Motahareh Mirdoosti Seyedeh Motahareh Mirdoosti 100319475328460015482 100319475328460015482 No Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran Farimah Beheshti Farimah Beheshti 100319475328460015483 100319475328460015483 No Neurocognitive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Neurocognitive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mahmoud Hosseini Mahmoud Hosseini 100319475328460015484 100319475328460015484 No Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Sajad Sahab Negah Sajad Sahab Negah 100319475328460015485 100319475328460015485 No a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Ali Gorji Ali Gorji gorjial@uni-muenster.de 100319475328460015486 100319475328460015486 Yes a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran c. Epilepsy Research Center, Department of Neurology, and Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany a. Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran c. Epilepsy Research Center, Department of Neurology, and Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany