The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1397
1
1
gregorian
2018
4
1
6
2
online
1
fulltext
en
P12: Protective Effects of Nigella Sativa on Synaptic Plasticity Impairment Induced by Lipopolysaccharide
P12: Protective Effects of Nigella Sativa on Synaptic Plasticity Impairment Induced by Lipopolysaccharide
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
پژوهشي
Research --- Open Access, CC-BY-NC
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<p style="text-align: justify;">In the present study the protective effect of Nigella sativa (N. sativa) on synaptic plasticity impairment induced by lipopolysaccharide (LPS) in rats was investigated. Fifty-eight rats were grouped and treated as follows: 1) control (saline), 2) LPS, 3) LPS-N. sativa, and 4) N. sativa. In a Morris water maze test, the escape latency and travelled path to find the platform as well as time spent and the travelled distance in target quadrant (Q1) were measured. Long term potentiation (LTP) from CA1 area of hippocampus followed by high frequency stimulation to Schafer collateral was studied and slope, slope 10-90% and amplitude of field excitatory field potential (fEPSP) were calculated. The escape latency and traveled path in LPS group were significantly higher than those in the control group while, in LPS-N. sativa group these parameters were significantly lower than those in LPS group. The rats in LPS group spent less time and travelled shorter distance in Q1 than the rats in the control group while, in LPS-N. sativa group the rats spent more time and travelled longer distance than the rats in LPS group. LPS significantly decreased slope, slope 10-90% and amplitude of fEPSP while, in LPS-N. sativa group these parameters increased compared to LPS group. The results indicated that the hydro-alcohol extract of N. sativa protected against synaptic plasticity and spatial learning and memory impairment induced by LPS in rats.</p>
Lipopolysaccharide, Long Term Potentiation, Nigella Sativa L, Spatial Memory, Synaptic Plasticity
43
43
http://shefayekhatam.ir/browse.php?a_code=A-10-24-1129&slc_lang=en&sid=1
Farimah
Beheshti
Farimah
Beheshti
100319475328460015487
100319475328460015487
No
a. Department of Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran b. Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
a. Department of Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran b. Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Akbar
Anaeigoudari
Akbar
Anaeigoudari
100319475328460015488
100319475328460015488
No
Department of Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Department of Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Fatemeh
Norouzi
Fatemeh
Norouzi
100319475328460015489
100319475328460015489
No
Department of Physiology, Esfarayan University of Medical Sciences, Esfarayan, Iran
Department of Physiology, Esfarayan University of Medical Sciences, Esfarayan, Iran
Azam
Abareshi
Azam
Abareshi
100319475328460015490
100319475328460015490
No
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Naser
Shafei
Mohammad Naser
Shafei
100319475328460015491
100319475328460015491
No
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Zahra
Gholamnezhad
Zahra
Gholamnezhad
100319475328460015492
100319475328460015492
No
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud
Hosseini
Mahmoud
Hosseini
hosseinim@mums.ac.i
100319475328460015493
100319475328460015493
Yes
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran