en P39: The Neuroprotection Effect of Erythropoietin in Cerebral Ischemia تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p style="text-align: justify;">Cerebral ischemia causes death of millions people all over the world, annually and also suffering more people from neurological deficits and neuromuscular disorders. In our country, 250 to 300 people experience mild to severe stroke, daily. In this study we reviewed 120 original paper selected from PubMED database. Our keywords were erythropoietin, anti-inflammatory, stroke, neuropathy and cerebral ischemia. Studies have been revealed that anti-inflammatory and neuroprotection effects of erythropoietin are mediated by receptors that available in cerebral cortex, spinal cord, hypothalamus and hippocampus. These effects include the ability to repair neural inflammation, prevention of neural cell death, preservation of surviving neural cells, regulation of neurogenesis, anti-apoptosis and anti-coagulation. Erythropoietin also prevents Alzheimer&#39;s disease, Parkinson&#39;s disease, epilepsy, multiple sclerosis, and other motor diseases. All studies showed that erythropoietin has anti-inflammatory and neuroprotection properties and can decrease probability of cerebral ischemia, impressively. Today, erythropoietin is considered as an attractive and effective therapeutic approach to cerebral ischemia; one of the most common causes of morbidity and mortality around the world.</p> Erythropoietin, Anti-Inflammatory, Stroke, Neuroprotection, Ischemic Brain 70 70 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1180&slc_lang=en&sid=1 Mohammad Shabani Mohammad Shabani mohammadshabaniii77@gmail.com 100319475328460016136 100319475328460016136 Yes Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran Fatemeh Barzegar Fatemeh Barzegar 100319475328460016137 100319475328460016137 No Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran Alireza Talaei Seyyed Alireza Talaei 100319475328460016138 100319475328460016138 No Physiology Research Center, Kashan University of Medical Scienes, Kashan, Iran Physiology Research Center, Kashan University of Medical Scienes, Kashan, Iran