The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1397
1
1
gregorian
2018
4
1
6
2
online
1
fulltext
en
P104: Obesity-Induced Neuroinflammation: Focus on Hypothalamic Inflammation
P104: Obesity-Induced Neuroinflammation: Focus on Hypothalamic Inflammation
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
<div style="text-align: center;"><span style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">.</span></span></span></span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;"></span></span></span></div>
<div style="text-align: justify;">Obesity is a Health issue around the world. Obesity is not limited to body weight, generally associated with low grade inflammation and with a cluster of disorders generally referred to as "metabolic syndrome". Regarding obesity and relapse, long-term concentration was set on the hypothalamus. Most recently,obesity- Originated neuroinflammation has been shown to affect other brain structures such as the hippocampus,cortex, brainstem, oramygdala. Additionally, obesity is accompanied by an increase in central disturbances such as depression and cognitive impairment. The hypothalamus is a key brain region in the regulation of energy balance. The hypothalamus is a key brain region in regulating energy balance. Especially controls food intake and both energy storage and expenditure through integration of humoral, neural and nutrient-related signals. The hypothalamus cells and glial cells act jointly to orchestrate. We discuss the effects and mechanisms of obesity- originated neuroinflammation, with a specific emphasis on extra-hypothalamic structures, as well as the consequences of neuroinflammation for some cerebral functions. Therefore, the existence of a causal link between hypothalamic inflammation and deregulations of feeding behavior, such as involuntary weight-loss or obesity, has been recommended. Among the inflammatory mediators that could induce deregulations of hypothalamic control of the energy balance, chemokines represent interesting candidates. Chemokines, primarily known for their chemical absorption role of immune cells to the inflamed site, have also been recommended capable of neuromodulation.</div>
Obesity, Neuroinflammation, Hypothalamus
135
135
http://shefayekhatam.ir/browse.php?a_code=A-10-24-1280&slc_lang=en&sid=1
Maryam
Moghadam
Maryam
Moghadam
Maryammghdm20@gmail.com
100319475328460015863
100319475328460015863
Yes
Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Zahra
Sheidae Mehne
Zahra
Sheidae Mehne
100319475328460015864
100319475328460015864
No
Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran