fa O18: Vague Nerve Stimulation تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; text-align: center; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></div> <strong>VNS indications</strong><br> <strong>Epilepsy </strong><br> VNS Therapy system is indicated for use as an adjunctive therapy in reducing the frequency of seizures in patients whose epileptic disorder is dominated by partial seizures (with or without secondary generalization) or generalized seizures that are refractory to antiepileptic medications.<br> <strong>Depression </strong><br> VNS Therapy is indicated for the adjunctive long-term treatment of chronic or recurrent depression who are experiencing a major depressive episode and have not had an adequate response to four or more antidepressant treatments.<br> <strong>Mechanism of action</strong><br> VNS definitely exerts an effect via the LC (norepinephrine) and the RN (serotonin)<br> These mechanisms of action are similar to those of medications through pharmacologic pathways<br> The LC and RN/DRN have been conclusively identified as: <ul> <li>Brain centers affected by VNS Therapy</li> <li>Playing a role in suppressing seizures</li> <li>Areas that must be intact for VNS Therapy to have an effect</li> </ul> <strong>VNS Safety Profile</strong><br> More than 70,000 patients worldwide have been implanted with VNS Therapy<br> No known interactions with medications<br> No reported systemic neurotoxic effects, rash, renal impairment, or bone marrow suppression<br> No increase in sudden, unexpected death in epilepsy (SUDEP)1<br> Gestational outcomes<br> Animal study has shown no evidence of impaired fertility or harm to the fetus due to VNS Therapy2,3<br> Pregnancies have gone to term with VNS4,5<br> <strong>One of my challenging Cases which resulted in Vague Nerve Stimulation (VNS) therapy</strong><br> 53-year-old Right-handed gentleman with History of epilepsy since 1983 (due to being injured during war) in form of CPS and GTCs.<br> We implanted VNS for the first time in Khatam-Al-Anbia hospital about three months ago for this patient.<br> The frequency of the patient&rsquo;s attacks has been decreased to about eighty percent till now.<br> No significant side effects have been reported except for mild hoarseness.<br> &nbsp; VNS Therapy, Epilepsy, Systemic Neurotoxic Effects 18 18 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1323&slc_lang=fa&sid=1 Nasser Zangiabadi Nasser Zangiabadi N.zangiabadi@gmail.com 100319475328460016802 100319475328460016802 Yes Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran