fa P13: Aquaporins Function as a Novel Therapeutic Strategy for a Variety of Cerebral Disorders تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; text-align: center; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></div> <strong>Introduction:</strong> Some cells have specialized channels in their plasma membranes that allow water to be transported though the lipid bilayer much more expeditiously than by simple diffusion which said &ldquo;aquaporins&rdquo;.&nbsp; The aquaporins are a family of membrane proteins that perform as water channels in several cell varieties and tissues in which fluid transport is crucial, like the gastrointestinal tract, lung, secretory glands, and brain. A family of transmembrane molecules knowns as aquaporins facilitate the movement of water across cellular compartments.&nbsp;<strong>Conclusion:&nbsp;</strong>The critical role of Aquaporin-4 (AQP4) is in mediating water fluxes in response to neuronal activity and maybe in seizure-induced edema. Therefore, function or expression modulation of AQP4 in a variety of brain disorders includinghydrocephalus, tumor, stroke, and epilepsy can be suggested as a new therapeutic strategy. Therapeutic Strategy, Aquaporins, Epilepsy, Water Channels 40 40 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1333&slc_lang=fa&sid=1 Zeinab Najmi Zeinab Najmi 100319475328460016840 100319475328460016840 Yes Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Mostafa Modarres Mousavi Mostafa Modarres Mousavi modarres.mousavi@gmail.com 100319475328460016841 100319475328460016841 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran