The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1393
6
1
gregorian
2014
9
1
2
3
online
1
fulltext
en
P92: Investigation of the Role of Glucocorticoid Receptors on the Anxiety in Mice: A Preliminary Report
P92: Investigation of the Role of Glucocorticoid Receptors on the Anxiety in Mice: A Preliminary Report
روانشناسی
Psycology
پژوهشي
Research --- Open Access, CC-BY-NC
<p align="center">لطفاً به لینک انگلیسی مراجعه شود. </p>
Some studies suggested that glucocorticoid receptors activities can modulate fear and anxiety. According to that, the purpose of this research is to assess the modulatory effect of glucocorticoid receptors on the anxiety assessed in plus maze. In this research mice with medium weight of 20-25 g were used. The male and female animals separately sorted in two groups as control and experiment randomly. For experiment groups 0.5-1 mg/kg dexamethasone was intraperitoneally injected as glucocorticoid receptors agonist and for control groups normal saline was injected thirty minutes before test. Before test, mice were put in black wall box for five minutes till their curiousness and movement activities are improved. While assessing their anxiety, the standard indicators were recorded for five minutes through observation. This study indicated that the dexamethasone in experiment groups reduces the anxiety. In comparison with control groups, they needed a significant longer period of time to pass on the arm of the maze (P<0.01). This result shows that glucocorticoid receptors activities have important modulatory role in anxiety reactions in plus maze assessment model.
Anxiety, Glucocorticoid, Plus Maze, Mice
116
116
http://shefayekhatam.ir/browse.php?a_code=A-10-24-145&slc_lang=en&sid=1
Sepideh
Amiri
Sepideh
Amiri
amiri.sp65@yahoo.com
10031947532846002295
10031947532846002295
Yes
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Ashkan
Divanbeigi
Ashkan
Divanbeigi
10031947532846002296
10031947532846002296
No
Institute for Cognitive Sciences Studies (ICSS), Tehran, Iran.
Institute for Cognitive Sciences Studies (ICSS), Tehran, Iran.