en P141: Role of Dopamine in Anxiety Behavior روانشناسی Psycology مروری Review --- Open Access, CC-BY-NC <p align="center">لطفأ به لینک انگلیسی مراجعه شود. </p> The mesolimbic dopamine (DA) system contains both D1-like and D2-like receptors, has been connected to control of locomotor behavior. An apparent role for D1 and D2 receptors throughout the mesolimbic system in the alteration of locomotor behavior has been demonstrated in pharmacological studies. The nucleus accumbens (NAc) is comprised of a core and a shell subregion, which is a component of the mesolimbic DA system, and has been specifically implicated in locomotor behavior. Intra-NAc injections of D1 and D2 agonists have been found to increase locomotor activity. The DA system also plays a role in regulating anxiety-like and fear behavior. Pharmacological studies have shown that D1 and D2 receptors are involved in anxiety-like behavior. Findings seem to be dictated by a number of factors, including strain, route of administration, ligand selected and behavioral test. Fear behavior may often be indiscernible from anxiety-like behavior in animal models though the anatomical aspects may be different. Fear cues have been shown to decrease DA transmission in the NAc core, but increase transmission in the shell. Dopamine release in the NAc also appears to assist in encoding cues that predict punishment avoidance. These data suggest a role between fear and DA transmission and suggest that there may also be a role of accumbal DA in anxiety-like behavior. Dopamine, Anxiety, Locomotion, Nucleus Accumbens 165 165 http://shefayekhatam.ir/browse.php?a_code=A-10-24-195&slc_lang=en&sid=1 Shahin Mohammad Sadeghi Shahin Mohammad Sadeghi 10031947532846002718 10031947532846002718 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sajad Sahab Negah Sajad Sahab Negah sahabsajad@yahoo.com 10031947532846002719 10031947532846002719 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Zabihollah Khaksar Zabihollah Khaksar 10031947532846002720 10031947532846002720 No Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Hadi Kazemi Hadi Kazemi 10031947532846002721 10031947532846002721 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. Hadi Aligholi Hadi Aligholi 10031947532846002722 10031947532846002722 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846002723 10031947532846002723 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Amin Afsahi Amin Afsahi 10031947532846002724 10031947532846002724 No Health Office Expert in Tehran Municipality-District 20, Tehran, Iran. Health Office Expert in Tehran Municipality-District 20, Tehran, Iran.