fa W3: A Controllable Brain Injury Model with a Defined Size for Evaluation of Tissue Engineered Products جراحی مغز و اعصاب Neurosurgery پژوهشي Research --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> Brain injury has a multiple pathophysiology for which there is no definite treatment. In this regard, tissue engineering is one of the probable strategies for repair of damaged tissue. But creating a proper model for testing the engineered products faced some difficulties, specially, when we want to evaluate the effects of a product on the volume of injury. The current brain injury methods couldn’t provide defined brain tissue damage. We propose a new method to solve the problem. Previously, we introduced a new method for harvesting subventricular tissue from adult rat brain using a modified semi-automatic biopsy needle. We showed that a defined volume of tissue harvested from a specific area of brain without any adverse effect on other regions. We suggest using this biopsy procedure for creating a brain injury model with a defined size. Using this controllable biopsy method, we can test engineered products in a rat model of brain injury and assessed the volume of cavity after performing treatments in different groups. Brain Injury, Subventricular Tissue, Biopsy 46 46 http://shefayekhatam.ir/browse.php?a_code=A-10-24-392&slc_lang=fa&sid=1 Hadi Aligholi Hadi Aligholi aligholihadi@gmail.com 10031947532846005606 10031947532846005606 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Maryam Safahani Maryam Safahani 10031947532846005607 10031947532846005607 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran. Sajad Sahab Negah Sajad Sahab Negah 10031947532846005608 10031947532846005608 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846005609 10031947532846005609 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.