fa W5: Animal Models of Spinal Cord Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> Spinal cord injury (SCI) leads to a significant health problem associated with a broad range of secondary complications and disabilities. In this regard, animal models can help us to understand the pathobiology of SCI and evaluate the effects of potential treatments for SCI. In contusion models of SCI, different devices including surgical spring-loaded clips, balloons, forceps, weights and the computer-controlled reproducible impact contusion devices were used to create a defined lesion in the spinal cord. To evaluate treatments that target axon regeneration or in case of implantations, transection models may be utilized in which an incision is created into spinal cord. The transection may be complete or incomplete. The unilateral hemisection injury can be a good alternative to complete transection in which structural integrity, function of one side of the spinal cord and bladder and bowel function were preserved. By choosing an appropriate SCI method, we can test numerous possibilities for novel therapeutic strategies before clinical investigations. Spinal Cord Injury, Animal Models, Therapeutic Strategies 48 48 http://shefayekhatam.ir/browse.php?a_code=A-10-24-394&slc_lang=fa&sid=1 Hadi Aligholi Hadi Aligholi aligholihadi@gmail.com 10031947532846005613 10031947532846005613 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Maryam Safahani Maryam Safahani 10031947532846005614 10031947532846005614 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran. Sajad Sahab Negah Sajad Sahab Negah 10031947532846005615 10031947532846005615 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846005616 10031947532846005616 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.