fa W7: In Vitro Traumatic Brain Injury Models تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> Traumatic brain injury (TBI) is caused by rapid deformation of the brain, resulting in a cascade of pathological events and ultimately neurodegeneration. In vitro models of TBI can help us to describe the pathobiological mechanisms. In vitro models of brain injury support a platform for performing repeatable, well-controlled, environmentally isolated experiments. Other advantages of in vitro models of injury are monitoring in real time and evaluation of specific region. Acute preparations, organotypic cultures, dissociated primary cultures, and immortalized cell line have been used to study neural injury in vitro. Several in vitro models of TBI have been designed, they include the following: Transection: in vitro transection models leading to axotomy. Compression: this model of TBI can be induced primary and secondary injury by the impactor. Hydrostatic pressure: using transient or static pressure, deformation is induced. Fluid shear stress: culture cells have been deformed using a fluid shear forces. Shear strain: in vitro shear strain model has been simulated for closed-head TBI. Stretch injury models: in vitro models of Stretch injury have been developed to reproduce the mechanics which occur during in vivo TBI. Using appropriate in vitro models, we can understand mechanisms of injury in details and evaluate the effects of potential treatments. In vitro, TBI, Injury, Pathobiology 50 50 http://shefayekhatam.ir/browse.php?a_code=A-10-24-396&slc_lang=fa&sid=1 Sajad Sahab Negah Sajad Sahab Negah sahabsajad@yahoo.com 10031947532846005623 10031947532846005623 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran. Hadi Aligholi Hadi Aligholi 10031947532846005624 10031947532846005624 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shahin Mohammad Sadeghi Shahin Mohammad Sadeghi 10031947532846005625 10031947532846005625 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846005626 10031947532846005626 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.