The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1393
9
1
gregorian
2014
12
1
2
4
online
1
fulltext
fa
P7: Salutary Effects of Progesterone for Traumatic Brain Injury
P7: Salutary Effects of Progesterone for Traumatic Brain Injury
نورولوژی
Neurology
پژوهشي
Research --- Open Access, CC-BY-NC
<p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p>
The sex hormone progesterone has been shown to improve outcomes in animal models and two early-phase trials involving patients with traumatic brain injury (TBI). The aim of this clinical study was to assess the effect of progesterone on the improvement of neurologic outcome in patients with diffuse and acute TBI. A prospective, randomized, double-blind trial of progesterone was conducted in our teaching hospital. A total of 50 patients with diffuse acute TBI who arrived within 4 hours of injury with a Glasgow Coma Score ≤ 12 were enrolled in the study. In a randomized style, 25 received progesterone (1 mg/kg per 12 h for 5 days) and 25 did not. The primary efficacy endpoint was the Glasgow Outcome Scale score 3 months after brain injury. Secondary efficacy endpoint included the mortality. The demographic characteristics and the mechanism of injury were similar for the two groups. After 3 months of treatment, the Glasgow Outcome Scale score analysis exhibited more favorable outcome among the patients who were given progesterone compared with the control individuals (P=0.05). The mortality rate of the control group was 20.8%, whereas any of patients in progesterone group did not die. Instances of complications and adverse events associated with the administration of progesterone were not found in any of patients. Our data suggest that the administration of progesterone for diffuse and acute TBI patients improved neurologic outcomes and reduced mortality. These results indicate that progesterone can considered as a promising neuroprotective drug.
Traumatic Brain Injury, Progesterone, Glasgow Outcome Scale
57
57
http://shefayekhatam.ir/browse.php?a_code=A-10-24-403&slc_lang=fa&sid=1
Zahra
Soltani
Zahra
Soltani
10031947532846005654
10031947532846005654
No
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Behshad
Mofid
Behshad
Mofid
10031947532846005655
10031947532846005655
No
Department of Neurosurgery, Kerman Hospital of Shahid Bahonar, Kerman, Iran.
Department of Neurosurgery, Kerman Hospital of Shahid Bahonar, Kerman, Iran.
Nader
Shahrokhi
Nader
Shahrokhi
10031947532846005656
10031947532846005656
No
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Mohammad
Khaksari
Mohammad
Khaksari
mkhaksari@kmu.ac.ir
10031947532846005657
10031947532846005657
Yes
Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Saeed
Karamouzian
Saeed
Karamouzian
10031947532846005658
10031947532846005658
No
Department of Neurosurgery, Kerman Hospital of Shahid Bahonar, Kerman, Iran.
Department of Neurosurgery, Kerman Hospital of Shahid Bahonar, Kerman, Iran.
Nouzar
Nakhaeei
Nouzar
Nakhaeei
10031947532846005659
10031947532846005659
No
Department of Social Medicine, Medical School of Afzalipour, Kerman University of Medical Sciences, Kerman, Iran.
Department of Social Medicine, Medical School of Afzalipour, Kerman University of Medical Sciences, Kerman, Iran.
Mehdi
Ahmadinejad
Mehdi
Ahmadinejad
10031947532846005660
10031947532846005660
No
Department of Intensive Care Unit, Kerman Hospital of Shahid Bahonar, Kerman, Iran.
Department of Intensive Care Unit, Kerman Hospital of Shahid Bahonar, Kerman, Iran.