fa P7: Salutary Effects of Progesterone for Traumatic Brain Injury نورولوژی Neurology پژوهشي Research --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> The sex hormone progesterone has been shown to improve outcomes in animal models and two early-phase trials involving patients with traumatic brain injury (TBI). The aim of this clinical study was to assess the effect of progesterone on the improvement of neurologic outcome in patients with diffuse and acute TBI. A prospective, randomized, double-blind trial of progesterone was conducted in our teaching hospital. A total of 50 patients with diffuse acute TBI who arrived within 4 hours of injury with a Glasgow Coma Score ≤ 12 were enrolled in the study. In a randomized style, 25 received progesterone (1 mg/kg per 12 h for 5 days) and 25 did not. The primary efficacy endpoint was the Glasgow Outcome Scale score 3 months after brain injury. Secondary efficacy endpoint included the mortality. The demographic characteristics and the mechanism of injury were similar for the two groups. After 3 months of treatment, the Glasgow Outcome Scale score analysis exhibited more favorable outcome among the patients who were given progesterone compared with the control individuals (P=0.05). The mortality rate of the control group was 20.8%, whereas any of patients in progesterone group did not die. Instances of complications and adverse events associated with the administration of progesterone were not found in any of patients. Our data suggest that the administration of progesterone for diffuse and acute TBI patients improved neurologic outcomes and reduced mortality. These results indicate that progesterone can considered as a promising neuroprotective drug. Traumatic Brain Injury, Progesterone, Glasgow Outcome Scale 57 57 http://shefayekhatam.ir/browse.php?a_code=A-10-24-403&slc_lang=fa&sid=1 Zahra Soltani Zahra Soltani 10031947532846005654 10031947532846005654 No Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Behshad Mofid Behshad Mofid 10031947532846005655 10031947532846005655 No Department of Neurosurgery, Kerman Hospital of Shahid Bahonar, Kerman, Iran. Department of Neurosurgery, Kerman Hospital of Shahid Bahonar, Kerman, Iran. Nader Shahrokhi Nader Shahrokhi 10031947532846005656 10031947532846005656 No Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Mohammad Khaksari Mohammad Khaksari mkhaksari@kmu.ac.ir 10031947532846005657 10031947532846005657 Yes Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran. Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran. Saeed Karamouzian Saeed Karamouzian 10031947532846005658 10031947532846005658 No Department of Neurosurgery, Kerman Hospital of Shahid Bahonar, Kerman, Iran. Department of Neurosurgery, Kerman Hospital of Shahid Bahonar, Kerman, Iran. Nouzar Nakhaeei Nouzar Nakhaeei 10031947532846005659 10031947532846005659 No Department of Social Medicine, Medical School of Afzalipour, Kerman University of Medical Sciences, Kerman, Iran. Department of Social Medicine, Medical School of Afzalipour, Kerman University of Medical Sciences, Kerman, Iran. Mehdi Ahmadinejad Mehdi Ahmadinejad 10031947532846005660 10031947532846005660 No Department of Intensive Care Unit, Kerman Hospital of Shahid Bahonar, Kerman, Iran. Department of Intensive Care Unit, Kerman Hospital of Shahid Bahonar, Kerman, Iran.