fa P46: Therapeutic Potential of Neural Stem Cells for Spinal Cord Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> Spinal cord injury (SCI) is a destructive condition that the cord can't send signals below the level of the injury. Despite advances in the medical and surgical care of SCI patients, no effective treatment exists for the neurological deficits of SCI. Cell therapy is a new approach for SCI, and preclinical models demonstrate that cell transplantation can improve some secondary events through neuroprotection and also restore lost tissue through regeneration. Neural Stem Cells (NSCs) are multipotent cells committed to the neural lineage that can self-renew. NSCs are found in both fetal and adult central nervous system (CNS). NSCs locate within specific niches in the adult CNS, including the subventricular zone in the lateral ventricles of the forebrain, the dentate gyrus of the hippocampus, olfactory bulb and the region of the central canal of the spinal cord. Transplantation of NSCs into injured tissue, promoted functional recovery with neuroprotective and neuroregenerative effects. Most studies with transplanted NSCs have shown modest recovery of the injured spinal cord. Adult mouse brain–derived NSCs transplanted into the injured rat spinal cord with concomitant infusion of growth factors promoted oligodendrocyte differentiation of the grafted NSCs, remyelination, and improved locomotor function. NSCs derived from fetal rat spinal cord differentiated into neurons that integrated into the injured cord and improved recovery, and transplanted NSCs combined with valproic acid administration promoted neuronal differentiation, resulting in restoration of disrupted neuronal circuitry and enhanced recovery. NSCs have also demonstrated some immunomodulatory and pathotropic ability by homing toward damaged tissue as well as secreting various neurotrophic factors and cytokines. Neuralstem cells also express nerve growth factors that are essential to the healthy function of the CNS. These could protect the patient’s own neurons from further degeneration due to injury. By solving some limitations in future, cell therapy can open a new window for treatment of SCI. Neural Stem Cells, Spinal Cord Injury, Cell Therapy 96 96 http://shefayekhatam.ir/browse.php?a_code=A-10-24-443&slc_lang=fa&sid=1 Sajad Sahab Negah Sajad Sahab Negah 10031947532846005853 10031947532846005853 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Hadi Aligholi Hadi Aligholi 10031947532846005854 10031947532846005854 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846005855 10031947532846005855 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Zabihollah Khaksar Zabihollah Khaksar 10031947532846005856 10031947532846005856 No Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Hadi Kazemi Hadi Kazemi 10031947532846005857 10031947532846005857 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. Shahin Mohammad Sadeghi Shahin Mohammad Sadeghi drshmsadeghi@gmail.com 10031947532846005858 10031947532846005858 Yes Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.