fa P47: Application of Induced Pluripotent Stem Cells in Spinal Cord Injury Treatment تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> Stem cell therapy can be useful for spinal cord injury (SCI). Induced pluripotent stem cells (iPSCs) are generated by reprogramming mature, fully differentiated cells into a pluripotent state. The ability to generate pluripotent cells from adult somatic cells without the need for an embryo was a major development in stem cell biology. iPSCs were established from mouse fibroblasts and demonstrated therapeutic potential for treating SCI in animal models. It has been reported that the human iPSCs differentiated into neurons, astrocytes, and oligodendrocytes in the injured spinal cord and promoted motor functional recovery. It is hypothesized that the transplantation of human iPSCs could result in a wide range of positive effects, including angiogenesis, axonal regeneration, and local-circuitry reconstruction. Recent study has demonstrated that iPSCs cells possess properties of embryonic stem cells generated from Patients with amyotrophic lateral sclerosis can be differentiated into motor neurons. Our hypothesis suggests that human iPSCs represent a promising cell source for transplantation into the injured spinal cord. Induced Pluripotent Stem Cells, Spinal Cord Injury, Transplantation, Axonal Regeneration 97 97 http://shefayekhatam.ir/browse.php?a_code=A-10-24-444&slc_lang=fa&sid=1 Sajad Sahab Negah Sajad Sahab Negah 10031947532846006196 10031947532846006196 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Hadi Aligholi Hadi Aligholi 10031947532846006197 10031947532846006197 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846006198 10031947532846006198 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Zabihollah Khaksar Zabihollah Khaksar 10031947532846006199 10031947532846006199 No Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Hadi Kazemi Hadi Kazemi 10031947532846006200 10031947532846006200 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. Shahin Mohammad Sadeghi Shahin Mohammad Sadeghi drshmsadeghi@gmail.com 10031947532846006201 10031947532846006201 Yes Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.