fa P49: The Role of Extra Cellular Matrix in Brain Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> Traumatic brain injury (TBI) results from a sudden and external physical impact to the head, and often leads to motor and cognitive impairment. Using tissue engineering strategies, we aimed to review aspects of extra cellular matrix (ECM) based scaffold that could be delivered to the injured brain. The ECM is produced intracellularly and secreted to form a dense network of proteins and glycans, occupying the parenchyma of virtually all cells. It is a source of diverse molecular signals that guide cellular growth, activity and survival. It is well known that changes to the ECM inhibit axonal regeneration it is also becoming clear that such alterations, particularly chondroitin sulphate proteoglycans (CSPGs) accumulation, impair oligodendrocyte function and remyelination. In order to enhance therapeutic efficacy, many studies have reported benefits from remodeling the extracellular matrix to provide a suitable scaffold for regeneration of cells and axons. Therefore, due to the effects of various ECM components on signaling events, it is very difficult to design controlled experiments for ECM-based cell signaling. It is also difficult to gelatinize nano or picogram quantities of collagen or the other single ECM component alone. Meanwhile, our ability to maintain stable cell density throughout experiments is limited when using several cell lines that do not have consistent adherence to culture flasks. ECM can be focused in basic investigations for understanding its roles and making engineered scaffolds mimicking ECM to treat SCI. Traumatic Brain Injury, ECM, Cell Signaling 99 99 http://shefayekhatam.ir/browse.php?a_code=A-10-24-446&slc_lang=fa&sid=1 Shahin Mohammad Sadeghi Shahin Mohammad Sadeghi 10031947532846005871 10031947532846005871 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sajad Sahab Negah Sajad Sahab Negah 10031947532846005872 10031947532846005872 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Hadi Kazemi Hadi Kazemi 10031947532846005873 10031947532846005873 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. Hadi Aligholi Hadi Aligholi 10031947532846005874 10031947532846005874 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846005875 10031947532846005875 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Zabihollah Khaksar Zabihollah Khaksar khaksar@sirazu.ac.ir 10031947532846005876 10031947532846005876 Yes Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.