fa P58: Neurological Outcomes after Traumatic Brain Injury Affected by Concomitant Administration of Progesterone and Erythropoietin نوروفارماکولوژی Neuropharmacology پژوهشي Research --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> Traumatic brain injury (TBI) is one of the most common neurological diseases with no definite treatment. Erythropoietin (Epo) and progesterone (Prog) have been shown to have neuroprotective effects in different types of experimental brain injury models. This study was designed to determine the effect of Epo, Prog and combination of Epo/Prog on neurological outcome after traumatic brain injury. Fifty-four male Wistar rats were divided into 5 groups including intact (n=6), TBI (n=12), TBI + 16 mg/kg Prog (n=12), TBI + 5000 U/kg Epo (n=12), TBI + 16 mg/kg Pro + 5000 U/kg Epo (n=12). Neurological evaluation was performed using modified Neurological Severity Score on days 1, 2, 7 and 14 post TBI. The results revealed that Prog and Epo individually ameliorated neurological deficit following TBI while the combination of Prog and Epo exacerbated the neurological dysfunction. In conclusion, our study indicates that the combination of Prog and Epo does not improve neurologic outcome after TBI. Traumatic Brain Injury, Progesterone, Neuroprotective 108 108 http://shefayekhatam.ir/browse.php?a_code=A-10-24-455&slc_lang=fa&sid=1 Zahra Nourzad Zahra Nourzad 10031947532846006202 10031947532846006202 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Tahere Ghadiri Tahere Ghadiri 10031947532846006203 10031947532846006203 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Arezou Eshaghabadi Arezou Eshaghabadi 10031947532846006204 10031947532846006204 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi modarres.mousavi@gmail.com 10031947532846006205 10031947532846006205 Yes Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.