The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1393
9
1
gregorian
2014
12
1
2
4
online
1
fulltext
fa
P59: Triazine Improved Hippocampal Injuries in Animal Model of Alzheimer’s Disease
P59: Triazine Improved Hippocampal Injuries in Animal Model of Alzheimer’s Disease
نوروپاتولوژي
Neuropathology
پژوهشي
Research --- Open Access, CC-BY-NC
<p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p>
Triazine derivatives are small synthetic peptides with no apparent toxicity and high target specificity in central nervous system. Hippocampal tissue is the most vulnerable area in the Alzheimer’s disease (AD). The aim of this study was to investigate the neuroprotective effect of triazine in AD induced by intra-cerebro-ventricular (i.c.v.) administration of streptozotocine (STZ). Male Wistar, weighting 200-250 grams were bilaterally implanted with chronic cannula in the Lateral ventricle. Animals were divided into seven groups Control group: animals received no surgery and treatment. Saline group: animals received normal saline after recovery. Sham group: animals received 10% DMSO after recovery. STZ group (Alzheimer’s model): animals received STZ in four and six days after recovery. T5, T10 and T15 groups: animals were treated with triazine derivative, C16H12Cl2N3S, at doses of 5, 10 and 15 µM, respectively. All drugs were injected i.c.v. To assess the neuroprotective effect of triazine, we measured the hippocampal CA1 pyramidal layer thickness in all tested groups. The CA1 pyramidal layer thicknesses in STZ group reduced significantly compared to control group. Triazine increased the CA1 pyramidal layer thickness in T15 group compared to STZ group. Our findings suggest that triazine may have protective effect on the hippocampus.
Alzheimer’s Disease, Triazine, Streptozotocine
109
109
http://shefayekhatam.ir/browse.php?a_code=A-10-24-457&slc_lang=fa&sid=1
Fatemeh
Alipour
Fatemeh
Alipour
10031947532846006039
10031947532846006039
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Fariba
Karimzadeh
Fariba
Karimzadeh
fariba_karimzade@yahoo.com
10031947532846006040
10031947532846006040
Yes
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Gholamreza
Hasanzadeh
Gholamreza
Hasanzadeh
10031947532846006041
10031947532846006041
No
Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran.