fa P60: Laminin Based Tissue Engineering for Central Nervous System Regeneration تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> Central nervous system (CNS) architecture damages, which can be induced by physical injuries during road accidents, often result in the loss of neuronal cell bodies, axons, and associated glia support. But, there is no currently definite treatment for CNS degeneration. Tissue engineering aims to restore the function of living tissues by replacing damaged tissues or organs. Natural or synthetic scaffolds that match the mechanical properties of the native tissue can be used to foster the growth of cells. Cell–cell adhesion and cell–extra cellular matrix (ECM) adhesion are crucial for tissue formation and maintenance of structural integrity. Tissue engineering strategies can involve analyzing the interactions between cells and the ECM, and evaluated changes in cell behavior in various contexts. Identification of binding sites and key motifs in ECM proteins that interact with cellular receptors will allow researchers to generate small peptides that can mimic the function of large ECM proteins. It is crucial that these small peptides are able to interact with the same cell surface receptor(s) as their parent ECM molecule and activate the appropriate signaling pathways that are consistent with the phenotype expected. One of the important ECM proteins is laminins consisting of α, β, and γ chains. Laminins are required for basement membrane assembly and they regulate cellular behavior through interactions with cell surface receptors, including integrins, syndecans, and α-dystroglycan. Recent studies showed that recombinant laminin-511 E8 (α5β1γ1) fragments are useful matrices for maintaining human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Using this system, hESCs and hiPSCs can be easily and stably passaged by dissociating the cells into single cells for long periods, without any karyotype abnormalities. The use of laminin-511 may provide permissive microenvironments to enhance cell survival and control neural stem cell fate, both in vitro and in vivo by holding and precisely delivering stem cell based treatments for CNS regeneration. Human Embryonic Stem Cell, Tissue Engineering, Laminin 110 110 http://shefayekhatam.ir/browse.php?a_code=A-10-24-458&slc_lang=fa&sid=1 Shahin Mohammad Sadeghi Shahin Mohammad Sadeghi 10031947532846006042 10031947532846006042 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Plastic Surgery Group, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Plastic Surgery Group, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sajad Sahab Negah Sajad Sahab Negah 10031947532846006043 10031947532846006043 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Hadi Kazemi Hadi Kazemi 10031947532846006044 10031947532846006044 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. Arezou Eshaghabadi Arezou Eshaghabadi 10031947532846006045 10031947532846006045 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Hadi Aligholi Hadi Aligholi 10031947532846006046 10031947532846006046 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846006047 10031947532846006047 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Zabihollah Khaksar Zabihollah Khaksar khaksar@shirazu.ac.ir 10031947532846006048 10031947532846006048 Yes Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.