The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1393
9
1
gregorian
2014
12
1
2
4
online
1
fulltext
fa
P63: Application of Nanofibrous Scaffolds with Biomolecules as a Promise Approach for Reconstruction of Peripheral Nerve Injury
P63: Application of Nanofibrous Scaffolds with Biomolecules as a Promise Approach for Reconstruction of Peripheral Nerve Injury
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
<p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p>
Peripheral nerve injuries caused by traffic accidents, resections of tumors or iatrogenic side effects of the surgeries are few of the most common form of trauma occurring with up to 500,000 cases each year in Iran. Conventional strategies including nerve coaptation, and the application of autografts, allografts and xenografts are restricted due to the limited availability of donors, immune-rejections or restrictions such as too big gap length. At the same time, these alternatives do not guarantee full recovery and functionality of the damaged nerves. Due to these reasons, approaches towards the development of biomaterial scaffolds for regeneration of peripheral nerve defects have gained a huge momentum. An ideal scaffold for nerve tissue regeneration requires sufficient biological and physiochemical properties, with major concern on biocompatibility, biodegradability, permeability for oxygen and nutrition, mechanical properties together with appropriate surface characteristics. The design of the engineered scaffold shall focus on mimicking the complex biological nanofibrous structure of the native extracellular matrix allowing the remodeling and repair of the damaged tissue by neighboring cell. Synthetic polymers such as poly-L-lactic acid and poly-e-caprolactone have been utilized to fabricate electrospunnanofibrous scaffolds and their compatibility towards peripheral nerve tissue regeneration has been investigated. However synthetic polymers alone might not meet all the requirements of an artificial tissue construct since they lack recognition sites for cell adhesion. Incorporating natural polymers, like proteins or peptides might overcome this problem and increase the biocompatibility of the scaffolds. Functionalization of nanofibers is usually performed by electrospinning of synthetic and natural polymer blends or by coating the nanofibrous scaffolds with biomolecules. Core–shell nanofibers prepared by co-axial electrospinning allows for the encapsulation of proteins within the core of the polymeric shell, thus may be preserving the bioactivity of the proteins or biomolecules better than blended or coated structures.
Nanofibrous Scaffold, Road Accident, Poly-L-Lactic Acid, Poly-e-Caprolactone
113
113
http://shefayekhatam.ir/browse.php?a_code=A-10-24-461&slc_lang=fa&sid=1
Shahin
Mohammad Sadeghi
Shahin
Mohammad Sadeghi
10031947532846005921
10031947532846005921
No
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Plastic Surgery Group, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Plastic Surgery Group, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hadi
Aligholi
Hadi
Aligholi
10031947532846005922
10031947532846005922
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Zabihollah
Khaksar
Zabihollah
Khaksar
10031947532846005923
10031947532846005923
No
Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.
Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.
Hadi
Kazemi
Hadi
Kazemi
10031947532846005924
10031947532846005924
No
Pediatric Department, Shahed University, Tehran, Iran.
Pediatric Department, Shahed University, Tehran, Iran.
Arezou
Eshaghabadi
Arezou
Eshaghabadi
10031947532846005925
10031947532846005925
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Mostafa
Modarres Mousavi
Mostafa
Modarres Mousavi
10031947532846005926
10031947532846005926
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Sajad
Sahab Negah
Sajad
Sahab Negah
sahabsajad@yahoo.com
10031947532846005927
10031947532846005927
Yes
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.